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May 1974, Vol 127, No. 5 >
Article | May 1974

Hemolytic Uremic Syndrome Associated With Infectious Mononucleosis FREE

George G. Shashaty, MD; Muvaffak A. Atamer, MD
[+] Author Affiliations

Received for publication June 15, 1973; accepted Dec 28.

Reprint requests to Department of Medicine, Georgetown University School of Medicine, Washington, DC 20007 (Dr. Shashaty).


Am J Dis Child. 1974;127(5):720-722. doi:10.1001/archpedi.1974.02110240106016.
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A 14-year-old boy with infectious mononucleosis developed typical hemolytic uremic syndrome (HUS). No response was noted to heparin sodium therapy but marked improvement occurred with prednisone therapy. To our knowledge, this is the first reported association between these two diseases, and suggests an additional pathogenetic mechanism for HUS.

REFERENCES

1 +
Brain MC:  Hemolytic uremic syndrome . Semin Hematol 6:162-182, 1969;.
2 +
Gianantonio C et al:  The hemolytic uremic syndrome . J Pediatr 64:478-491, 1964;.
Link to Article
3 +
Lieberman E et al:  Hemolytic uremic syndrome . N Engl J Med 275:227-230, 1966;.
Link to Article
4 +
Clarkson AR et al:  Hemolytic uremic syndrome in adults . Q J Med 154:227-244, 1970;.
5 +
Shapiro CM et al:  Hemolytic uremic syndrome in adults . JAMA 213:567-570, 1970;.
Link to Article
6 +
Ray CG et al:  Enteroviruses associated with the hemolytic-uremic syndrome . Pediatrics 46:378-388, 1970;.
7 +
Mettler NE:  Isolation of a microtatobiote from patients with hemolytic-uremic syndrome . N Engl J Med 281:1023-1207, 1969;.
Link to Article
8 +
Leavitt TJ, Merigan TC, Freeman JM:  Hemolytic uremic-like syndrome following polycarboxylate interferon induction . Amer J Dis Child 121:43-47, 1971;.
9 +
Brain MC:  Microangiopathic hemolytic anemia . Annu Rev Med 21:133-152, 1970;.
Link to Article
10 +
Hammond D, Lieberman E:  The hemolytic uremic syndrome: Renal cortical thrombotic microangiopathy . Arch Intern Med 126:816-822, 1970;.
Link to Article
11 +
Vitsky BH et al:  Hemolytic uremic syndrome: Study of renal pathological alterations . Amer J Pathol 57:627-647, 1969;.
12 +
Vassalli P, Simon G, Rouiller C:  Electron microscopic study of glomerular lesions due to intravascular fibrin formation . Amer J Pathol 43:579-618, 1963;.
13 +
Vassalli P, McCluskey RT:  The coagulation process and glomerular disease . Amer J Med 39:179- 181, 1965;.
Link to Article
14 +
Carter RL, Penman HG: Infectious Mononucleosis , Oxford, England, Blackwell Scientific Publications, 1969;, p 35.
15 +
Peters JH, Flume J, Fuccilla D:  Nephritis in infectious mononucleosis . Clin Res 10:254, 1962;.
16 +
Tennant FS:  The glomerulonephritis of infectious mononucleosis . Tex Rep Biol Med 26:603-612, 1968;.
17 +
Parker JC, Barrett DA:  Microangiopathic hemolysis and thrombocytopenia related to penicillin drugs . Arch Intern Med 127:474-478, 1971;.
Link to Article
18 +
Chessin LN et al:  The circulating lymphocyte–its role in infectious mononucleosis . Ann Intern Med 69:333-359, 1968;.
Link to Article
19 +
Capra JD, Winchester RJ, Kunkel HG:  Cold reactive rheumatoid factors in infectious mononucleosis and other diseases . Arthritis Rheum 12:67-73, 1969;.
Link to Article
20 +
Hossaini AA:  Anti-i in infectious mononucleosis . Amer J Clin Pathol 53:198-203, 1970;.
21 +
Birndorf NI, Lopas H, Robboy SJ:  Disseminated intravascular coagulation and renal failure . Lab Invest 25:314-319, 1971;.
22 +
Carter RL:  Platelet levels in infectious mononucleosis . Blood 25:817-823, 1965;.
23 +
Clancy R, Jenkins E, Firkin B:  Platelet defect of infectious mononucleosis . Br Med J 4:646-648, 1971;.
Link to Article
24 +
Avalos JS et al:  Coagulation studies in the hemolytic uremic syndrome . J Pediatr 76:538-548, 1970;.
Link to Article
25 +
Willoughby MLN et al:  Coagulation studies in hemolytic uremic syndrome . Arch Dis Child 47:716-722, 1972;.
Link to Article

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References

1 +
Brain MC:  Hemolytic uremic syndrome . Semin Hematol 6:162-182, 1969;.
2 +
Gianantonio C et al:  The hemolytic uremic syndrome . J Pediatr 64:478-491, 1964;.
Link to Article
3 +
Lieberman E et al:  Hemolytic uremic syndrome . N Engl J Med 275:227-230, 1966;.
Link to Article
4 +
Clarkson AR et al:  Hemolytic uremic syndrome in adults . Q J Med 154:227-244, 1970;.
5 +
Shapiro CM et al:  Hemolytic uremic syndrome in adults . JAMA 213:567-570, 1970;.
Link to Article
6 +
Ray CG et al:  Enteroviruses associated with the hemolytic-uremic syndrome . Pediatrics 46:378-388, 1970;.
7 +
Mettler NE:  Isolation of a microtatobiote from patients with hemolytic-uremic syndrome . N Engl J Med 281:1023-1207, 1969;.
Link to Article
8 +
Leavitt TJ, Merigan TC, Freeman JM:  Hemolytic uremic-like syndrome following polycarboxylate interferon induction . Amer J Dis Child 121:43-47, 1971;.
9 +
Brain MC:  Microangiopathic hemolytic anemia . Annu Rev Med 21:133-152, 1970;.
Link to Article
10 +
Hammond D, Lieberman E:  The hemolytic uremic syndrome: Renal cortical thrombotic microangiopathy . Arch Intern Med 126:816-822, 1970;.
Link to Article
11 +
Vitsky BH et al:  Hemolytic uremic syndrome: Study of renal pathological alterations . Amer J Pathol 57:627-647, 1969;.
12 +
Vassalli P, Simon G, Rouiller C:  Electron microscopic study of glomerular lesions due to intravascular fibrin formation . Amer J Pathol 43:579-618, 1963;.
13 +
Vassalli P, McCluskey RT:  The coagulation process and glomerular disease . Amer J Med 39:179- 181, 1965;.
Link to Article
14 +
Carter RL, Penman HG: Infectious Mononucleosis , Oxford, England, Blackwell Scientific Publications, 1969;, p 35.
15 +
Peters JH, Flume J, Fuccilla D:  Nephritis in infectious mononucleosis . Clin Res 10:254, 1962;.
16 +
Tennant FS:  The glomerulonephritis of infectious mononucleosis . Tex Rep Biol Med 26:603-612, 1968;.
17 +
Parker JC, Barrett DA:  Microangiopathic hemolysis and thrombocytopenia related to penicillin drugs . Arch Intern Med 127:474-478, 1971;.
Link to Article
18 +
Chessin LN et al:  The circulating lymphocyte–its role in infectious mononucleosis . Ann Intern Med 69:333-359, 1968;.
Link to Article
19 +
Capra JD, Winchester RJ, Kunkel HG:  Cold reactive rheumatoid factors in infectious mononucleosis and other diseases . Arthritis Rheum 12:67-73, 1969;.
Link to Article
20 +
Hossaini AA:  Anti-i in infectious mononucleosis . Amer J Clin Pathol 53:198-203, 1970;.
21 +
Birndorf NI, Lopas H, Robboy SJ:  Disseminated intravascular coagulation and renal failure . Lab Invest 25:314-319, 1971;.
22 +
Carter RL:  Platelet levels in infectious mononucleosis . Blood 25:817-823, 1965;.
23 +
Clancy R, Jenkins E, Firkin B:  Platelet defect of infectious mononucleosis . Br Med J 4:646-648, 1971;.
Link to Article
24 +
Avalos JS et al:  Coagulation studies in the hemolytic uremic syndrome . J Pediatr 76:538-548, 1970;.
Link to Article
25 +
Willoughby MLN et al:  Coagulation studies in hemolytic uremic syndrome . Arch Dis Child 47:716-722, 1972;.
Link to Article

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