Lymphoid hyperplasia of the intestinal tract is a nonspecific reactive change. In most instances it is associated with a benign clinical course and requires no treatment. It has been noted in association with several specific disease entities, but most often the cause has not been defined. Medications such as steroids have been shown to hasten the disappearance of severe symptoms and roentgenographic signs. Occasionally, surgery may be required because of the inability to make a satisfactory preoperative diagnosis or in the face of severe complications. Major surgical resection is indicated in some cases. The six cases reported herein show a variety of manifestations and confirm that this is not always a benign disease.