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Comparative Serological Changes Following Treated Group A Streptococcal Pharyngitis

Benjamin K. Silverman, MD; Robert H. Bierman, MD; David Atkin, MD; Norman S. Katz, MD; Jan D. Janeff, MD; Donka G. Janeff, MD
Am J Dis Child. 1974;127(4):498-501. doi:10.1001/archpedi.1974.02110230044006.
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Sequential serum samples from 100 children with documented group A streptococcal pharyngitis treated with orally given penicillin were examined with antistreptolysin and Streptozyme tests.

The Streptozyme test was positive with all sera with antistreptolysin titers [unk] 166 Todd units. Serum samples showing low antistreptolysin and elevated Streptozyme titers had an increased antihyaluronidase or antideoxyribonuclease B titer, or both, in more than 50% of the cases.

Patients with low initial antistreptolysin and Streptozyme titers, on reexamination one month later, exhibited statistically significant titer increase. These levels, however, still remained below the accepted "normal" levels.


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