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January 1974, Vol 127, No. 1 >
Article | January 1974

Cord Blood Hypertriglyceridemia FREE

Reginald Tsang, MB, BS; Charles J. Glueck, MD; Grace Evans; Paula M. Steiner
[+] Author Affiliations

Received for publication May 28, 1973; accepted Aug 13.

Reprint requests to General Clinical Research Center, Cincinnati General Hospital, 234 Goodman St, Room C 2-3, Cincinnati 45229.


Am J Dis Child. 1974;127(1):78-82. doi:10.1001/archpedi.1974.02110200080011.
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Comments

Cord blood triglyceride (TG) concentrations were determined in 60 neonates whose parents had normal plasma cholesterol and triglyceride levels, and in 57 neonates with one parent having primary hypertriglyceridemia. The 95th percentile value for cord blood triglyceride in both groups of neonates was 70 mg/100 ml, and this level was arbitrarily used as a cutoff point in the definition of cord blood hypertriglyceridemia. In 2,000 consecutive live births, 56 neonates had cord blood triglyceride levels > 70 mg/100 ml (mean TG 111±33, range 71 to 218 mg/100 ml). Forty-six neonates with triglyceride levels <70 mg/100 ml (mean TG 31, range 1 to 70 mg/100 ml) were selected as controls. Cord blood hypertriglyceridemia was highly associated with maternal-fetal problems, including maternal hypertension, prolonged duration of labor, umbilical cord around the infant's neck, meconium-stained amniotic fluid, postterm delivery, and decreased one-minute Apgar scores. For all neonates studied (102) there was a linear relationship between the number of significant perinatal factors and the cord blood triglyceride level (r = 0.61, P <.001). Hypertriglyceridemia at birth may be a useful indication of intrapartum or antepartum fetal stress or compromise.

REFERENCES

1 +
Glueck CJ, et al:  Neonatal familial type II hyperlipoproteinemia: Cord blood cholesterol in 1,800 births . Metabolism 20:597-608, 1971;.
Link to Article
2 +
Kwiterovich P, Levy RI, Fredrickson DS:  Neonatal diagnosis of familial type II hyperlipoproteinemia . Lancet 1:118-121, 1973;.
Link to Article
3 +
Glueck CJ, et al:  Pediatric familial type IV hyperlipoproteinemia , abstracted. Clin Res 20:632, 1972;.
4 +
Glueck CJ, et al:  Pediatric familial type IV hyperlipoproteinemia . Trans Assoc Am Physicians 85:139-150, 1972;.
5 +
Glueck CJ, et al:  Familial hypertriglyceridemia: Studies in 130 children and 45 siblings of 36 index cases . Metabolism 22:1287-1309, 1973;.
Link to Article
6 +
Glueck CJ, Tsang RC:  Pediatric familial type II hyperlipoproteinemia: Effects of diet on plasma cholesterol in the first year of life . Am J Clin Nutr 25:224-230, 1972;.
7 +
Fredrickson DS, Levy RI:  Familial hyperlipoproteinemias , in Stanbury JB, Wyngaarden JB, Fredrickson DS (eds): The Metabolic Basis of Inherited Disease , ed 3. New York, McGraw-Hill Book Co Inc, 1972;, pp 545-614.
8 +
White P:  Symposium on diabetes mellitus: Pregnancy complicating diabetes . Am J Med 7:609-616, 1949;.
Link to Article
9 +
Kessler G, Lederer H:  Fluorimetric measurement of triglycerides , in Skeggs LT Jr (ed): Automation in Analytical Chemistry . New York, Mediad, 1966;, p 341.
10 +
Snedecor GW, Cochran WG: Statistical Methods , ed 6. Ames, Iowa, Iowa State University Press, 1964;.
11 +
Brody S, Carlson LA:  Plasma lipid concentrations in the newborn with special reference to the distribution of the different lipid fractions . Clin Chim Acta 7:694-699, 1962;.
Link to Article
12 +
Zee P:  Lipid metabolism in the newborn: II. Neutral lipids . Pediatrics 41:640-645, 1968;.
13 +
Kaplan A, Lee VF:  Serum lipid levels in infants and mothers at parturition . Clin Chim Acta 12:258-263, 1965;.
Link to Article
14 +
Wille LE, Phillips GB:  Lipoprotein and lipid composition of neonatal serum . Clin Chim Acta 34:457-462, 1971;.
Link to Article
15 +
Barnes K, et al:  Neonatal plasma lipids . Med J Aust 2:1002-1005, 1972;.
16 +
Hillman LM, Pritchard JA: Obstetrics , ed 14. New York, Appleton-Century-Crofts Inc, 1971;, pp 1007-1058.
17 +
Gruenwald P:  Chronic fetal distress and placental insufficiency . Biol Neonat 5:215-265, 1963;.
Link to Article
18 +
Van Duyne CM, Havel RJ:  Plasma unesterified fatty acid concentration in fetal and neonatal life . Proc Soc Exp Biol Med 102:599-602, 1959;.
19 +
Rafstedt S:  Studies on serum lipids and lipoproteins in infancy and childhood . Acta Paediatr Scand 102( (suppl) ):1-109, 1955;.
20 +
Senn MJE, McNamara H:  The lipids of the blood plasma in the neonatal period . Am J Dis Child 53:445-454, 1937;.
21 +
Chen CC, et al:  The plasma free fatty acid composition and blood glucose of normal and diabetic pregnant women and of their newborns . Pediatrics 36:843-855, 1965;.
22 +
Persson B, Gentz J:  The pattern of blood lipids, glycerol and ketone bodies during the neonatal period, infancy and childhood . Acta Paediatr Scand 55:353-362, 1966;.
23 +
Novak M, et al:  Levels of lipids in the blood of newborn infants and the effect of glucose administration . Physiol Bohemoslov 10:488-492, 1961;.
24 +
Novak M, et al:  Release of free fatty acids from adipose tissue obtained from newborn infants . J Lipid Res 6:91-95, 1965;.
25 +
Havel RJ:  Conversion of plasma free fatty acids into triglycerides of plasma lipoprotein factions in man . Metabolism 10:1031-1034, 1961;.
26 +
Cornblath M, Schwartz R:  Carbohydrate homeostasis in the neonate , in Disorders of Carbohydrate Metabolism in Infancy , ed 1. Philadelphia, WB Saunders Co, 1966;, pp 33-54.
27 +
Goldwater WH, Stetten D Jr:  Studies in fetal metabolism . J Biol Chem 169:723-738, 1947;.
28 +
Roux JF, Takeda Y, Grigorian A:  Lipid concentration and composition in human fetal tissue during development . Pediatrics 48:540-546, 1971;.
29 +
Dawes GS: Foetal & Neonatal Physiology . Chicago, Year Book Medical Publisher Inc, 1968;, p 215.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Glueck CJ, et al:  Neonatal familial type II hyperlipoproteinemia: Cord blood cholesterol in 1,800 births . Metabolism 20:597-608, 1971;.
Link to Article
2 +
Kwiterovich P, Levy RI, Fredrickson DS:  Neonatal diagnosis of familial type II hyperlipoproteinemia . Lancet 1:118-121, 1973;.
Link to Article
3 +
Glueck CJ, et al:  Pediatric familial type IV hyperlipoproteinemia , abstracted. Clin Res 20:632, 1972;.
4 +
Glueck CJ, et al:  Pediatric familial type IV hyperlipoproteinemia . Trans Assoc Am Physicians 85:139-150, 1972;.
5 +
Glueck CJ, et al:  Familial hypertriglyceridemia: Studies in 130 children and 45 siblings of 36 index cases . Metabolism 22:1287-1309, 1973;.
Link to Article
6 +
Glueck CJ, Tsang RC:  Pediatric familial type II hyperlipoproteinemia: Effects of diet on plasma cholesterol in the first year of life . Am J Clin Nutr 25:224-230, 1972;.
7 +
Fredrickson DS, Levy RI:  Familial hyperlipoproteinemias , in Stanbury JB, Wyngaarden JB, Fredrickson DS (eds): The Metabolic Basis of Inherited Disease , ed 3. New York, McGraw-Hill Book Co Inc, 1972;, pp 545-614.
8 +
White P:  Symposium on diabetes mellitus: Pregnancy complicating diabetes . Am J Med 7:609-616, 1949;.
Link to Article
9 +
Kessler G, Lederer H:  Fluorimetric measurement of triglycerides , in Skeggs LT Jr (ed): Automation in Analytical Chemistry . New York, Mediad, 1966;, p 341.
10 +
Snedecor GW, Cochran WG: Statistical Methods , ed 6. Ames, Iowa, Iowa State University Press, 1964;.
11 +
Brody S, Carlson LA:  Plasma lipid concentrations in the newborn with special reference to the distribution of the different lipid fractions . Clin Chim Acta 7:694-699, 1962;.
Link to Article
12 +
Zee P:  Lipid metabolism in the newborn: II. Neutral lipids . Pediatrics 41:640-645, 1968;.
13 +
Kaplan A, Lee VF:  Serum lipid levels in infants and mothers at parturition . Clin Chim Acta 12:258-263, 1965;.
Link to Article
14 +
Wille LE, Phillips GB:  Lipoprotein and lipid composition of neonatal serum . Clin Chim Acta 34:457-462, 1971;.
Link to Article
15 +
Barnes K, et al:  Neonatal plasma lipids . Med J Aust 2:1002-1005, 1972;.
16 +
Hillman LM, Pritchard JA: Obstetrics , ed 14. New York, Appleton-Century-Crofts Inc, 1971;, pp 1007-1058.
17 +
Gruenwald P:  Chronic fetal distress and placental insufficiency . Biol Neonat 5:215-265, 1963;.
Link to Article
18 +
Van Duyne CM, Havel RJ:  Plasma unesterified fatty acid concentration in fetal and neonatal life . Proc Soc Exp Biol Med 102:599-602, 1959;.
19 +
Rafstedt S:  Studies on serum lipids and lipoproteins in infancy and childhood . Acta Paediatr Scand 102( (suppl) ):1-109, 1955;.
20 +
Senn MJE, McNamara H:  The lipids of the blood plasma in the neonatal period . Am J Dis Child 53:445-454, 1937;.
21 +
Chen CC, et al:  The plasma free fatty acid composition and blood glucose of normal and diabetic pregnant women and of their newborns . Pediatrics 36:843-855, 1965;.
22 +
Persson B, Gentz J:  The pattern of blood lipids, glycerol and ketone bodies during the neonatal period, infancy and childhood . Acta Paediatr Scand 55:353-362, 1966;.
23 +
Novak M, et al:  Levels of lipids in the blood of newborn infants and the effect of glucose administration . Physiol Bohemoslov 10:488-492, 1961;.
24 +
Novak M, et al:  Release of free fatty acids from adipose tissue obtained from newborn infants . J Lipid Res 6:91-95, 1965;.
25 +
Havel RJ:  Conversion of plasma free fatty acids into triglycerides of plasma lipoprotein factions in man . Metabolism 10:1031-1034, 1961;.
26 +
Cornblath M, Schwartz R:  Carbohydrate homeostasis in the neonate , in Disorders of Carbohydrate Metabolism in Infancy , ed 1. Philadelphia, WB Saunders Co, 1966;, pp 33-54.
27 +
Goldwater WH, Stetten D Jr:  Studies in fetal metabolism . J Biol Chem 169:723-738, 1947;.
28 +
Roux JF, Takeda Y, Grigorian A:  Lipid concentration and composition in human fetal tissue during development . Pediatrics 48:540-546, 1971;.
29 +
Dawes GS: Foetal & Neonatal Physiology . Chicago, Year Book Medical Publisher Inc, 1968;, p 215.

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