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January 1974, Vol 127, No. 1 >
Article | January 1974

Late Presentation of Drug Withdrawal Symptoms in Newborns FREE

Stephen R. Kandall, MD; Lawrence M. Gartner, MD
[+] Author Affiliations

Received for publication April 23, 1973; accepted Aug 30.

Reprint requests to Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 (Dr. Kandall).


Am J Dis Child. 1974;127(1):58-61. doi:10.1001/archpedi.1974.02110200060008.
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Significant symptoms of neonatal drug abstinence first occurred at between 2 and 4 weeks of age in seven infants. Irritability and tremulousness were the major late symptoms, and seizures occurred in four of the seven infants. One infant in whom the syndrome was not recognized showed progression of symptoms and died at 3 weeks of age. Although patterns of maternal drug-taking varied, methadone hydrochloride was taken in all cases; in two women, urine test findings confirmed methadone to be the only drug of abuse. Fetal accumulation and delayed excretion of the drugs may account for delayed onset of symptoms. Physicians caring for such high-risk infants should recognize the potential seriousness of this problem.

REFERENCES

1 +
Reddy AM, Harper RG, Stern G:  Observations on heroin and methadone withdrawal in the newborn . Pediatrics 48:353-357, 1971;.
2 +
Annunziato D:  Neonatal addiction to methadone . Pediatrics 47:787, 1971;.
3 +
Rajegowda BK, et al:  Methadone withdrawal in newborn infants . J Pediatr 81:532-534, 1972;.
Link to Article
4 +
Desmond MM, et al:  Maternal barbiturate utilization and neonatal withdrawal symptomatology . J Pediatr 80:190-197, 1972;.
Link to Article
5 +
Isbell H, Vogel VH:  The addiction liability of methadon (amidone, dolophine, 10820) and its use in the treatment of the morphine abstinence syndrome . Am J Psychiatry 105:909-914, 1949;.
6 +
Goodman LS, Gilman A:  Narcotic analgesics , in The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Co, 1970;, p 261.
7 +
Dole VP, Kreek MJ:  Methadone plasma level: Sustained by a reservoir of drug in tissue . Proc Natl Acad Sci USA 70:10, 1973;.
Link to Article
8 +
Davis MM, Brown BS, Glendinning ST: Neonatal effects of heroin addiction and methadonetreated pregnancies: Preliminary report on 70 live births, in 1973 Proceedings of Fifth National Conference on Methadone Treatment. New York, National Association for the Prevention of Addiction to Narcotics, 1973, pp 1153-1164.

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References

1 +
Reddy AM, Harper RG, Stern G:  Observations on heroin and methadone withdrawal in the newborn . Pediatrics 48:353-357, 1971;.
2 +
Annunziato D:  Neonatal addiction to methadone . Pediatrics 47:787, 1971;.
3 +
Rajegowda BK, et al:  Methadone withdrawal in newborn infants . J Pediatr 81:532-534, 1972;.
Link to Article
4 +
Desmond MM, et al:  Maternal barbiturate utilization and neonatal withdrawal symptomatology . J Pediatr 80:190-197, 1972;.
Link to Article
5 +
Isbell H, Vogel VH:  The addiction liability of methadon (amidone, dolophine, 10820) and its use in the treatment of the morphine abstinence syndrome . Am J Psychiatry 105:909-914, 1949;.
6 +
Goodman LS, Gilman A:  Narcotic analgesics , in The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Co, 1970;, p 261.
7 +
Dole VP, Kreek MJ:  Methadone plasma level: Sustained by a reservoir of drug in tissue . Proc Natl Acad Sci USA 70:10, 1973;.
Link to Article
8 +
Davis MM, Brown BS, Glendinning ST: Neonatal effects of heroin addiction and methadonetreated pregnancies: Preliminary report on 70 live births, in 1973 Proceedings of Fifth National Conference on Methadone Treatment. New York, National Association for the Prevention of Addiction to Narcotics, 1973, pp 1153-1164.

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