Three patients had echovirus infection in early infancy, two with type 6 and one with type 11. All three had a progressive clinical course complicated by disseminated intravascular coagulation. Postmortem findings in two neonates showed massive hepatic necrosis, aseptic meningitis, and varying amounts of adrenal and renal hemorrhage with necrosis. The third patient, who had severe combined immunodeficiency, became ill at 3 weeks of age with respiratory distress, went on to develop progressive sclerema, oliguria, and respiratory failure, and died at 2 months of age. Postmortem findings showed mild focal hepatic and myocardial necrosis. These cases add echovirus types 6 and 11 to the growing list of enteroviruses associated with disseminated intravascular coagulation, hepatic necrosis, meningitis, and death in neonates.