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November 1973, Vol 126, No. 5 >
Article | November 1973

Mediastinal Teratoma With Endocrine Function FREE

Richard E. Honicky, MD; Elise W. dePapp, MD
[+] Author Affiliations

Received for publication March 29, 1973; accepted June 17.

Reprint requests to Department of Pediatrics, Boston City Hospital, 818 Harrison Ave, Boston 02118 (Dr. Honicky).


Am J Dis Child. 1973;126(5):650-653. doi:10.1001/archpedi.1973.02110190522012.
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An insulin-producing teratoma of the mediastinum was found in a 5-year-old boy. Asymptomatic hypoglycemia and an elevated plasma level of immunoreactive insulin were noted preoperatively. After removal of the teratoma, which contained an abundance of islet cell tissue, both of these values returned to normal. This is, to our knowledge, the first report of a benign teratoma with such endocrine activity.

REFERENCES

1 +
Bolande RP: Cellular Aspects of Developmental Pathology . Philadelphia, Lea & Febiger, 1967;, p 102.
2 +
Pagliara AS, et al:  Hypoglycemia in infancy and children . J Pediatr 82:365-379, 1973;.
3 +
Kempers RD, et al:  Struma ovarii . Ann Intern Med 72:883-893, 1970;.
4 +
Berry CL, Keeling J, Hilton C:  Teratomata in infancy and childhood: A review of 91 cases . J Pathol 98:241-252, 1969;.
5 +
Chappell JS:  Teratomas in infancy and childhood . S Afr J Surg 8:77-85, 1970;.
6 +
Gwinn JL, Dockerty MD, Kennedy RLJ:  Presacral teratomas in infancy and childhood . Pediatrics 16:239-249, 1955;.
7 +
Adler RH, Taheri SA, Weintraub DH:  Mediastinal teratoma in infancy . J Thorac Cardiovasc Surg 19:394-404, 1960;.
8 +
Thompson DP, Moore TC:  Acute thoracic distress in childhood due to spontaneous rupture of a large mediastinal teratoma . J Pediatr Surg 4:416-423, 1969;.
9 +
Abell MR, Johnson VJ, Holtz F:  Ovarian neoplasms in childhood and adolescence . Am J Obstet Gynecol 92:1059-1081, 1965;.
10 +
Miller DW, Stewart CF, Rosner W:  Hypoglycemia caused by abdominal leiomyosarcoma . Am J Surg 119:754-757, 1970;.
11 +
Williams RH: Textbook of Endocrinology . Philadelphia, WB Saunders Co, 1969;, p 1215.

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References

1 +
Bolande RP: Cellular Aspects of Developmental Pathology . Philadelphia, Lea & Febiger, 1967;, p 102.
2 +
Pagliara AS, et al:  Hypoglycemia in infancy and children . J Pediatr 82:365-379, 1973;.
3 +
Kempers RD, et al:  Struma ovarii . Ann Intern Med 72:883-893, 1970;.
4 +
Berry CL, Keeling J, Hilton C:  Teratomata in infancy and childhood: A review of 91 cases . J Pathol 98:241-252, 1969;.
5 +
Chappell JS:  Teratomas in infancy and childhood . S Afr J Surg 8:77-85, 1970;.
6 +
Gwinn JL, Dockerty MD, Kennedy RLJ:  Presacral teratomas in infancy and childhood . Pediatrics 16:239-249, 1955;.
7 +
Adler RH, Taheri SA, Weintraub DH:  Mediastinal teratoma in infancy . J Thorac Cardiovasc Surg 19:394-404, 1960;.
8 +
Thompson DP, Moore TC:  Acute thoracic distress in childhood due to spontaneous rupture of a large mediastinal teratoma . J Pediatr Surg 4:416-423, 1969;.
9 +
Abell MR, Johnson VJ, Holtz F:  Ovarian neoplasms in childhood and adolescence . Am J Obstet Gynecol 92:1059-1081, 1965;.
10 +
Miller DW, Stewart CF, Rosner W:  Hypoglycemia caused by abdominal leiomyosarcoma . Am J Surg 119:754-757, 1970;.
11 +
Williams RH: Textbook of Endocrinology . Philadelphia, WB Saunders Co, 1969;, p 1215.

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