To the Editor.—Thank you very much for the opportunity to respond to the comments of Drs. Irving J. Wolman and Lewis B. Harden relevant to a paper we published in the Journal some time ago (123:204-206, 1972) entitled "Oral Antipyretic Therapy: Evaluation of Aspirin-Acetaminophen Combination."
Dr. Wolman's letter suggests that we claimed in our study that the two drugs acted synergistically in antipyretic effect when given together. He further indicated that the combination therapy cannot be considered to be superior to either drug alone unless additional controls receiving double the amount of each of the antipyretics evaluated separately were included for comparison. Actually, we claimed to show no more than an additive effect with the combination therapy and this was only in duration of antipyretic effect and not in the rate or degree of temperature reduction. We did not include additional controls receiving twice the recommended dose of