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Early Development of Infants of Heroin-Addicted Mothers FREE

Geraldine S. Wilson, MD; Murdina M. Desmond, MD; Willie M. Verniaud, EdD
[+] Author Affiliations

Received for publication Dec 27, 1972; accepted April 30, 1973.

Reprint requests to Baylor College of Medicine, Department of Pediatrics, 1200 Moursund Ave, Houston, TX 77025 (Dr. Wilson).


Am J Dis Child. 1973;126(4):457-462. doi:10.1001/archpedi.1973.02110190381004.
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The course of growth and development of 30 infants of heroin addicts was observed from 3 to 34 months.

Eighty percent had signs of neonatal withdrawal, while 60% continued with subacute withdrawal signs for three to six months.

Behavioral disturbances, predominantly hyperactivity, brief attention span, and temper outbursts, were identified in seven of 14 infants observed one year or longer, while two had neurological abnormality. Growth impairment was associated with behavioral disturbances in four of the seven. These disturbances appear to be unrelated to subsequent environmental factors.

Infants performed at age-appropriate levels on developmental testing.

REFERENCES

Perlstein MA:  Congenital morphinism: A rare cause of convulsions in the newborn . JAMA 135:633, 1947;.
Cobrinik RW, Hood TR, and Chusid E:  The effect of maternal narcotic addiction on the newborn infant: Review of the literature and report of 22 cases . Pediatrics 24:288-304, 1959;
Zelson C, Rubio E, Wasserman E:  Neonatal narcotic addiction: 10 year observation . Pediatrics 48:178-189, 1971;
Goodfriend MJ, Shey IA, Klein MD:  The effects of maternal narcotic addiction on the newborn . Am J Obstet Gynecol 71:29-36, 1956;.
Pettey GE:  Congenital morphinism, with report of cases . South Med J 5:25-28, 1912;.
Hill RM, Desmond MM:  Management of the narcotic withdrawal syndrome in the neonate . Pediatr Clin North Am 10:67-86, 1963;.
Lubchenco LO, Hansman C, Boyd E:  Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks . Pediatrics 37:403-408, 1966;.
Desmond MM, et al:  Maternal barbiturate utilization and neonatal withdrawal symptomatology . J Pediatr 80:190-197, 1972;.
Gesell A, Amatruda CS: Developmental Diagnosis . New York, Paul B. Hoeber, Inc, 1954;.
Stone M, et al:  Narcotic addiction in pregnancy . Am J Obstet Gynecol 109:716-723, 1971;.
Claman A, Strang R:  Obstetric and gynecologic aspects of heroin addiction . Am J Obstet Gynecol 83:252-257, 1962;.
Perlmutter JF:  Drug addiction in pregnant women . Am J Obstet Gynecol 99:569-572, 1967;.
Friedler G, Cochin J:  Growth retardation in offspring of female rats treated with morphine prior to conception . Science 175:654-656, 1972;.
Borison H: The Nervous System. Narcotic Drugs: Biochemical Pharmacology . DG Clouet (ed), New York, Plenum Press Inc, 1971;, pp 342-365.
Prechtl H:  The long term value of the neurological examination of the newborn infant . Little Club Clin Dev Med 2:29-74, 1960;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Perlstein MA:  Congenital morphinism: A rare cause of convulsions in the newborn . JAMA 135:633, 1947;.
Cobrinik RW, Hood TR, and Chusid E:  The effect of maternal narcotic addiction on the newborn infant: Review of the literature and report of 22 cases . Pediatrics 24:288-304, 1959;
Zelson C, Rubio E, Wasserman E:  Neonatal narcotic addiction: 10 year observation . Pediatrics 48:178-189, 1971;
Goodfriend MJ, Shey IA, Klein MD:  The effects of maternal narcotic addiction on the newborn . Am J Obstet Gynecol 71:29-36, 1956;.
Pettey GE:  Congenital morphinism, with report of cases . South Med J 5:25-28, 1912;.
Hill RM, Desmond MM:  Management of the narcotic withdrawal syndrome in the neonate . Pediatr Clin North Am 10:67-86, 1963;.
Lubchenco LO, Hansman C, Boyd E:  Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks . Pediatrics 37:403-408, 1966;.
Desmond MM, et al:  Maternal barbiturate utilization and neonatal withdrawal symptomatology . J Pediatr 80:190-197, 1972;.
Gesell A, Amatruda CS: Developmental Diagnosis . New York, Paul B. Hoeber, Inc, 1954;.
Stone M, et al:  Narcotic addiction in pregnancy . Am J Obstet Gynecol 109:716-723, 1971;.
Claman A, Strang R:  Obstetric and gynecologic aspects of heroin addiction . Am J Obstet Gynecol 83:252-257, 1962;.
Perlmutter JF:  Drug addiction in pregnant women . Am J Obstet Gynecol 99:569-572, 1967;.
Friedler G, Cochin J:  Growth retardation in offspring of female rats treated with morphine prior to conception . Science 175:654-656, 1972;.
Borison H: The Nervous System. Narcotic Drugs: Biochemical Pharmacology . DG Clouet (ed), New York, Plenum Press Inc, 1971;, pp 342-365.
Prechtl H:  The long term value of the neurological examination of the newborn infant . Little Club Clin Dev Med 2:29-74, 1960;.

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