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September 1973, Vol 126, No. 3 >
Article | September 1973

Congenital Anomalies and Herpesvirus Infection FREE

John R. Montgomery, MD; Raymond W. Flanders, MD; Martha D. Yow, MD
[+] Author Affiliations

Received for publication Nov 8, 1972; accepted May 19, 1973.

Reprint requests to 1200 Moursund Ave, Houston 77025 (Dr. Montgomery).


Am J Dis Child. 1973;126(3):364-366. doi:10.1001/archpedi.1973.02110190322017.
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Comments

A 14-month-old girl with chorioretinitis, patent ductus arteriosus, short digits with deformed nails, and growth and developmental retardation is described. Bullous lesions were present at birth and bouts of fever and vesicular skin lesions recurred periodically. Herpesvirus was cultured from the vesicular lesions and the patient's antibody response indicated infection with herpesvirus type II. It is postulated that the infection occurred in utero, produced the anomalies, and persisted to cause the recurring episodes of illness.

REFERENCES

1 +
Batignani A:  Congiuntivite da virus erpetico in neonato . Boll Ocul 13:1217-1220, 1934;.
2 +
Hass GM:  Hepato-adrenal necrosis with intranuclear inclusion bodies: A case report . Am J Pathol 11:127-142, 1935;.
3 +
Ekert H:  Coagulation abnormalities in generalized herpes simplex infection of newborn . Lancet 2:775-776, 1970;.
4 +
Guha DK, Rashmi A, Khanduja PC:  In utero infection of the fetus by herpes simplex virus . Indian J Pediatr 35:484-486, 1969;.
5 +
Hagler WS, Walters PV, Nahmias AJ:  Ocular involvement in neonatal herpes simplex virus infection . Arch Ophthalmol 82:169-176, 1969;.
6 +
Hovig DE, et al:  Herpesvirus hominis (simplex) infection in the newborn: With recurrences during infancy . Am J Dis Child 115:438-444, 1968;.
7 +
Miller DR, et al:  Fatal disseminated herpes simplex virus infection and hemorrhage in the neonate . J Pediatr 76:409-415, 1970;.
8 +
Nahmias AJ, Josey WE, Naib ZM:  Neonatal herpes simplex infection: Role of genital infection in mother as the source of virus in the newborn . JAMA 199:132-136, 1967;.
9 +
Schaffer M: Diseases of the Newborn , ed 2. Philadelphia, WB Saunders Co, 1965;, pp 733-734.
10 +
Shershow LW, et al:  Intravascular coagulation in the generalized herpes simplex infection of the newborn . Acta Paediatr Scand 58:535-539, 1969;.
11 +
Sieber OF, et al:  In utero infection of the fetus by herpes simplex virus . J Pediatr 69:30-34, 1966;.
12 +
South MA, et al:  Congenital malformation of the central nervous system associated with genital type (type 2) herpes virus . J Pediatr 75:13-18, 1969;.
13 +
Zuelzer WW, Stulberg CS:  Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy . Am J Dis Child 83:421-439, 1952;.
14 +
Rawls WE, et al:  Measurement of antibodies to herpesvirus types 1 and 2 in human sera . J Immunol 104:599-606, 1970;.
15 +
Lewis GM, Wheeler CA: Practical Dermatology , ed 3. Philadelphia, WB Saunders Co, 1967;, p 415, 590.
16 +
Witzleben CL, Driscoll SG:  Possible transplacental transmission of herpes simplex infection . Pediatrics 36:192-199, 1965;.
17 +
Rawls WE, et al:  Genital herpes in two social groups . Am J Obstet Gynecol 110:682-689, 1972;.
18 +
Terni M, et al:  Aseptic meningitis in association with herpes progenitalis . N Engl J Med 285:503-504, 1971;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Batignani A:  Congiuntivite da virus erpetico in neonato . Boll Ocul 13:1217-1220, 1934;.
2 +
Hass GM:  Hepato-adrenal necrosis with intranuclear inclusion bodies: A case report . Am J Pathol 11:127-142, 1935;.
3 +
Ekert H:  Coagulation abnormalities in generalized herpes simplex infection of newborn . Lancet 2:775-776, 1970;.
4 +
Guha DK, Rashmi A, Khanduja PC:  In utero infection of the fetus by herpes simplex virus . Indian J Pediatr 35:484-486, 1969;.
5 +
Hagler WS, Walters PV, Nahmias AJ:  Ocular involvement in neonatal herpes simplex virus infection . Arch Ophthalmol 82:169-176, 1969;.
6 +
Hovig DE, et al:  Herpesvirus hominis (simplex) infection in the newborn: With recurrences during infancy . Am J Dis Child 115:438-444, 1968;.
7 +
Miller DR, et al:  Fatal disseminated herpes simplex virus infection and hemorrhage in the neonate . J Pediatr 76:409-415, 1970;.
8 +
Nahmias AJ, Josey WE, Naib ZM:  Neonatal herpes simplex infection: Role of genital infection in mother as the source of virus in the newborn . JAMA 199:132-136, 1967;.
9 +
Schaffer M: Diseases of the Newborn , ed 2. Philadelphia, WB Saunders Co, 1965;, pp 733-734.
10 +
Shershow LW, et al:  Intravascular coagulation in the generalized herpes simplex infection of the newborn . Acta Paediatr Scand 58:535-539, 1969;.
11 +
Sieber OF, et al:  In utero infection of the fetus by herpes simplex virus . J Pediatr 69:30-34, 1966;.
12 +
South MA, et al:  Congenital malformation of the central nervous system associated with genital type (type 2) herpes virus . J Pediatr 75:13-18, 1969;.
13 +
Zuelzer WW, Stulberg CS:  Herpes simplex virus as the cause of fulminating visceral disease and hepatitis in infancy . Am J Dis Child 83:421-439, 1952;.
14 +
Rawls WE, et al:  Measurement of antibodies to herpesvirus types 1 and 2 in human sera . J Immunol 104:599-606, 1970;.
15 +
Lewis GM, Wheeler CA: Practical Dermatology , ed 3. Philadelphia, WB Saunders Co, 1967;, p 415, 590.
16 +
Witzleben CL, Driscoll SG:  Possible transplacental transmission of herpes simplex infection . Pediatrics 36:192-199, 1965;.
17 +
Rawls WE, et al:  Genital herpes in two social groups . Am J Obstet Gynecol 110:682-689, 1972;.
18 +
Terni M, et al:  Aseptic meningitis in association with herpes progenitalis . N Engl J Med 285:503-504, 1971;.

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