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July 1973, Vol 126, No. 1 >
Article | July 1973

Bacteroides Brain Abscess Treated With Clindamycin FREE

Najwa Khuri-Bulos, MD; Kenneth McIntosh, MD; Josephine Ehret
[+] Author Affiliations

Received for publication Aug 29, 1972; accepted March 14.

Reprint requests to Pediatric Infectious Disease, University of Colorado Medical Center, 4200 E Ninth Ave, Denver, CO 80220 (Dr. Khuri-Bulos).


Am J Dis Child. 1973;126(1):96-98. doi:10.1001/archpedi.1973.02110190084018.
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References
Comments

Clindamycin (7-chloro-7-deoxy lincomycin) is a semisynthetic antibiotic produced by the replacement of the 7-hydroxyl group by a halogen in the parent compound lincomycin. In clinical trials clindamycin has been found to be effective in eradicating thoracic, abdominal, and pelvic infections with bacteroides. This drug has not been tried in anaerobic central nervous system infections, however.

A 6-year-old girl developed urticaria following chloramphenicol administration for bacteroides brain abscess. Chloramphenicol was discontinued and in its place she was given clindamycin. She recovered completely after surgery and prolonged antibiotic therapy with clindamycin.

REFERENCES

1 +
Kaplan K, Weinstein L:  Lincomycin and Clinimycin (7 Chlorincomycin) , in Kagan BM (ed): Antimicrobial Therapy . WB Saunders Co, 1970;.
2 +
Bartlett JG, Sutter VL, Finegold SM:  Treatment of anaerobic infection with lincomycin and clindamycin . New Engl J Med 287:1006-1010, 1972;.
3 +
Heineman HS, Braude AI:  Anaerobic infections of the brain . Am J Med 35:682-697, 1963;.
4 +
Keusch GT, O'Connell CJ:  The susceptibility of bacteroides to the penicillins and cephalothin . Am J Med Sci 251:428-447, 1966;.
5 +
Sutter VL, Kwok YY, Finegold SM:  Standardised antimicrobial disc susceptibility testing of anaerobic bacteria: 1. Susceptibility of Bacteroides fragilis to tetracycline . Appl Microbiol 23:268-275, 1972;.
6 +
Kislak J:  The susceptibility of Bacteroides fragilis to 24 antibiotics . J Infect Dis 125:295-299, 1972;.
7 +
Ingham HR, et al:  A study in vitro of the sensitivity to antibiotics of Bacteroides fragilis . J Clin Pathol 21:432-436, 1968;.
8 +
Ingham HR, et al:  The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro . J Clin Pathol 23:254-258, 1970;.
9 +
Taber LH, Yow MD, Nieberg FG:  The penetration of broad spectrum antibiotics into the CSF . Ann New York Acad Sci 145:473-481, 1967;.
10 +
Sacks HJ:  Giant urticaria reaction due to Chloromycetin: Report of a case . Ann West Med Surg 3:249, 1949;.
11 +
Macewen W: Pyogenic Infective Diseases of the Brain and Spinal Cord . Glasgow, J Maclehose & Sons, 1893;, pp 332-334.
12 +
Jooma OV, Pennybacker JB, Tutton GK:  Brain abscess: Aspiration drainage or excision? J Neurol Neurosurg Psychiatry 14:308-313, 1951;.
13 +
Garfield J:  Management of supratentorial intracranial abscess: A review of 200 cases . Br Med J 2:7-11, 1969;.
14 +
Carey ME, Chow SN, French LA:  Experience with brain abscesses . J Neurosurg 36:1-9, 1972;.

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References

1 +
Kaplan K, Weinstein L:  Lincomycin and Clinimycin (7 Chlorincomycin) , in Kagan BM (ed): Antimicrobial Therapy . WB Saunders Co, 1970;.
2 +
Bartlett JG, Sutter VL, Finegold SM:  Treatment of anaerobic infection with lincomycin and clindamycin . New Engl J Med 287:1006-1010, 1972;.
3 +
Heineman HS, Braude AI:  Anaerobic infections of the brain . Am J Med 35:682-697, 1963;.
4 +
Keusch GT, O'Connell CJ:  The susceptibility of bacteroides to the penicillins and cephalothin . Am J Med Sci 251:428-447, 1966;.
5 +
Sutter VL, Kwok YY, Finegold SM:  Standardised antimicrobial disc susceptibility testing of anaerobic bacteria: 1. Susceptibility of Bacteroides fragilis to tetracycline . Appl Microbiol 23:268-275, 1972;.
6 +
Kislak J:  The susceptibility of Bacteroides fragilis to 24 antibiotics . J Infect Dis 125:295-299, 1972;.
7 +
Ingham HR, et al:  A study in vitro of the sensitivity to antibiotics of Bacteroides fragilis . J Clin Pathol 21:432-436, 1968;.
8 +
Ingham HR, et al:  The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro . J Clin Pathol 23:254-258, 1970;.
9 +
Taber LH, Yow MD, Nieberg FG:  The penetration of broad spectrum antibiotics into the CSF . Ann New York Acad Sci 145:473-481, 1967;.
10 +
Sacks HJ:  Giant urticaria reaction due to Chloromycetin: Report of a case . Ann West Med Surg 3:249, 1949;.
11 +
Macewen W: Pyogenic Infective Diseases of the Brain and Spinal Cord . Glasgow, J Maclehose & Sons, 1893;, pp 332-334.
12 +
Jooma OV, Pennybacker JB, Tutton GK:  Brain abscess: Aspiration drainage or excision? J Neurol Neurosurg Psychiatry 14:308-313, 1951;.
13 +
Garfield J:  Management of supratentorial intracranial abscess: A review of 200 cases . Br Med J 2:7-11, 1969;.
14 +
Carey ME, Chow SN, French LA:  Experience with brain abscesses . J Neurosurg 36:1-9, 1972;.

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