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The Thalassaemia Syndromes

John N. Lukens, MD
Am J Dis Child. 1973;125(6):904-905. doi:10.1001/archpedi.1973.04160060100031.
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The accelerating growth of the thalassemia literature threatens to boggle even the most conscientious of interested physicians. Weatherall's first edition of The Thalassaemia Syndromes, published in 1965, provided a much-needed synthesis of clinical and experimental experience culled from the world literature. It successfully bridged the communication gap between clinician and basic scientist concerned with the molecular control of protein synthesis. Obsolescence of the first volume was assured by the continuing evolution of concepts regarding the synthesis, structure, and function of hemoglobin. Consequently, the updated analysis of the subject necessitated complete rewriting of the first edition. In this more recent venture, Weatherall was joined by Clegg, who has pioneered in the development of methods which permit quantitative assessment of globin synthesis. The result is a logical interdigitation of molecular pathology with clinical and hematological observations. Throughout, complex subject matter is presented in an orderly, rational, and lucid manner. The volume stands


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