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March 1973, Vol 125, No. 3 >
Article | March 1973

Massive Intracranial Hemorrhage in Sickle-Cell Anemia FREE

Maria L. Falter, MD; Albert L. Sutton, MD; Margaret G. Robinson, MD
[+] Author Affiliations

Received for publication April 11, 1972; accepted Oct. 9.

Reprint requests to 450 Clarkson Ave, Brooklyn, NY (Dr. Falter).


Am J Dis Child. 1973;125(3):415-416. doi:10.1001/archpedi.1973.04160030073015.
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A 61/2-year-old black boy known to have sickle-cell anemia died shortly after developing sudden lethargy which progressed into unconsciousness. Bloodless spinal fluid suggested a diagnosis of cerebral thrombosis, but the postmortem examination revealed a massive subdural hemorrhage to be the cause of death. Although it is a rare complication, massive intracranial hemorrhage should be considered in the differential diagnosis in a child with sickle-cell anemia who shows acute neurological signs.

REFERENCES

1 +
Greer M, Schotland D:  Abnormal hemoglobin as a cause of neurological disease . Neurology 12:114-123, 1962;.
2 +
Kuntz A: A Textbook of Neuro-Anatomy , ed 5. Philadelphia, Lea and Febiger, 1950;, p 147.
3 +
Cook WC:  A case of sickle cell anemia associated with subarachnoid hemorrhage . J Med 11:541-542, 1930;.
4 +
Bridgers WN:  Cerebrovascular disease accompanying sickle cell disease . Am J Pathol 15:353-361, 1939;.
5 +
Riggs HE, Rupp C:  Clinico pathological conference . Neurology 4:705-709, 1954;.
6 +
Adeloye A, Ogbeide MI, Odeku EL:  Massive intracranial hemorrhage in sickle cell anemia . Neurology 20:1165-1170, 1970;.
7 +
Abildgaard CF, Simone JV, Schulman I:  Factor VIII (antihemophilic factor) activity in sickle-cell anemia . Br J Haematol 13:19-27, 1967;.
8 +
Mahmood A, Mac Intosh DM, Shaper AG:  Fibrinolytic activity in the clinical crisis of sickle cell anemia . Br J Haematol 13:19-27, 1967;.
9 +
Fink AI, et al:  Conjunctival blood flow in sickle cell disease responses to stimuli . Trans Am Acad Ophthalmol Otolaryngol 1964;, pp 301-315.
10 +
Fink AI, et al:  Conjunctival blood flow in sickle cell disease . Arch Ophthalmol 66:824-829, 1961;.
11 +
Mostofi FK, Vorder Bruegge CF, Diggs LW:  Lesions in kidneys removed for unilateral hematuria in sickle cell disease . Arch Pathol 63:336-351, 1957;.
12 +
Miller RE, et al:  Sickle cell nephropathy . Ala J Med Sci 1:233-238, 1964;.
13 +
Brain R: Diseases of the Nervous System , ed 5. Oxford, England, Oxford University Press, 1955;, p 308.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Greer M, Schotland D:  Abnormal hemoglobin as a cause of neurological disease . Neurology 12:114-123, 1962;.
2 +
Kuntz A: A Textbook of Neuro-Anatomy , ed 5. Philadelphia, Lea and Febiger, 1950;, p 147.
3 +
Cook WC:  A case of sickle cell anemia associated with subarachnoid hemorrhage . J Med 11:541-542, 1930;.
4 +
Bridgers WN:  Cerebrovascular disease accompanying sickle cell disease . Am J Pathol 15:353-361, 1939;.
5 +
Riggs HE, Rupp C:  Clinico pathological conference . Neurology 4:705-709, 1954;.
6 +
Adeloye A, Ogbeide MI, Odeku EL:  Massive intracranial hemorrhage in sickle cell anemia . Neurology 20:1165-1170, 1970;.
7 +
Abildgaard CF, Simone JV, Schulman I:  Factor VIII (antihemophilic factor) activity in sickle-cell anemia . Br J Haematol 13:19-27, 1967;.
8 +
Mahmood A, Mac Intosh DM, Shaper AG:  Fibrinolytic activity in the clinical crisis of sickle cell anemia . Br J Haematol 13:19-27, 1967;.
9 +
Fink AI, et al:  Conjunctival blood flow in sickle cell disease responses to stimuli . Trans Am Acad Ophthalmol Otolaryngol 1964;, pp 301-315.
10 +
Fink AI, et al:  Conjunctival blood flow in sickle cell disease . Arch Ophthalmol 66:824-829, 1961;.
11 +
Mostofi FK, Vorder Bruegge CF, Diggs LW:  Lesions in kidneys removed for unilateral hematuria in sickle cell disease . Arch Pathol 63:336-351, 1957;.
12 +
Miller RE, et al:  Sickle cell nephropathy . Ala J Med Sci 1:233-238, 1964;.
13 +
Brain R: Diseases of the Nervous System , ed 5. Oxford, England, Oxford University Press, 1955;, p 308.

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