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March 1973, Vol 125, No. 3 >
Article | March 1973

Disseminated Intravascular Coagulation in the Respiratory Distress Syndrome FREE

Carmi Z. Margolis, MD; Marcello M. Orzalesi, MD; Allen D. Schwartz, MD
[+] Author Affiliations

Received for publication April 14, 1972; accepted Oct 5.

Reprint requests to OMERAD, Fee Hall East, Michigan State University, East Lansing, Mich 48823 (Dr. Margolis).


Am J Dis Child. 1973;125(3):324-326. doi:10.1001/archpedi.1973.04160030010002.
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References
Comments

A study was planned to determine whether or not disseminated intravascular coagulation (DIC) contributes to the pathogenesis of idiopathic respiratory distress syndrome (IRDS) and to ascertain the possible role of DIC in the production of the intracranial hemorrhages (ICH) frequently found at autopsy in IRDS.

Conclusive evidence of DIC was found in only two of 11 infants; one had DIC on day one and died; the other developed DIC on day eight while on the respirator and survived. Four of the remaining nine infants died. Autopsies were performed on three and showed extensive hyaline membranes and atelectasis in all and severe ICH in two. No postmortem evidence of DIC was found.

These data do not suggest that DIC plays a major role in the pathogenesis of IRDS, nor that it is an important contributing factor in the high mortality and frequent ICH in IRDS.

REFERENCES

1 +
Boyd JF:  Two possible cases of acquired hypofibrinogenemia in the newborn . Surg Gynecol Obstet 106:176-178, 1958;.
2 +
Boyd JF:  Disseminated fibrin thromboembolism among neonates dying within 48 hours of birth . Arch Dis Child 42:401-409, 1965;.
3 +
Wade-Evans T:  Thrombi in the hepatic sinusoids of the newborn and their relation to pulmonary hyaline membrane formation . Arch Dis Child 36:286-292, 1961;.
4 +
Stark CR, Abramson D, Erkan V:  Intravascular coagulation and hyaline membrane disease of the newborn . Lancet 1:1180-1181, 1968;.
5 +
Markarian M, Lindley A, Jackson JJ:  Coagulation factors in pregnant women and premature infants with and without the respiratory distress syndrome . Thromb Diath Haemorrh 17:585-594, 1967;.
6 +
Schenk W, et al:  Intravascular coagulation and hyaline membrane disease . Lancet 2:1082, 1968;.
7 +
Becker MJ, Becker AE:  Intravascular coagulation and hyaline membrane disease . Lancet 2:170, 1968;.
8 +
Stark CR, Abramson D, Erkan V:  Intravascular coagulation and hyaline membrane disease . Lancet 2:520, 1968;.
9 +
Hathaway WE, Mull NN, Pechet GS:  Disseminated intravascular coagulation in the newborn . Pediatrics 43:233-238, 1969;.
10 +
Stiehm ER, Clatanoff DV:  Split products of fibrin in the serum of newborns . Pediatrics 43:770-780, 1969;. 1
11 +
Biggs R, Macfarlane RG:  Quantitative test for factor V deficiency , in Human Blood Coagulation . Oxford, Basil Blackwell & Mott Ltd, 1962;, p 288.
12 +
Poole JG, Robinson J:  Assay of plasma antihemophilic globulin (AHG) . Br J Haematol 5:17-23, 1959;.
13 +
Merskey C, Lalezari P, Johnson AJ:  A rapid, simple sensitive method for measuring fibrinolytic split products in human serum . Proc Soc Exp Biol Med 131:871-875, 1969;.
14 +
Breen FA, Tullis JL:  Ethanol gelation test improved . Ann Intern Med 71:433, 1969;.
15 +
Bleyer WA, Hakami N, Shepard TH:  The development of hemostasis in the human fetus and newborn infant . J Pediatr 79:838-853, 1971;.
16 +
Markarian M, et al:  Hypercoagulability in premature infants with special reference to the respiratory distress syndrome and hemorrhage: I. Coagulation studies . Biol Neonate 17:84-97, 1971;.
17 +
Markarian M, et al:  Hypercoagulability in premature infants with special reference to the respiratory distress syndrome and hemorrhage: II. The effect of heparin . Biol Neonate 17:98-111, 1971;.
18 +
McKay DG:  Progress in Disseminated Intravascular Coagulation . Calif Med 111:186-199, 279-290, 1969;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Boyd JF:  Two possible cases of acquired hypofibrinogenemia in the newborn . Surg Gynecol Obstet 106:176-178, 1958;.
2 +
Boyd JF:  Disseminated fibrin thromboembolism among neonates dying within 48 hours of birth . Arch Dis Child 42:401-409, 1965;.
3 +
Wade-Evans T:  Thrombi in the hepatic sinusoids of the newborn and their relation to pulmonary hyaline membrane formation . Arch Dis Child 36:286-292, 1961;.
4 +
Stark CR, Abramson D, Erkan V:  Intravascular coagulation and hyaline membrane disease of the newborn . Lancet 1:1180-1181, 1968;.
5 +
Markarian M, Lindley A, Jackson JJ:  Coagulation factors in pregnant women and premature infants with and without the respiratory distress syndrome . Thromb Diath Haemorrh 17:585-594, 1967;.
6 +
Schenk W, et al:  Intravascular coagulation and hyaline membrane disease . Lancet 2:1082, 1968;.
7 +
Becker MJ, Becker AE:  Intravascular coagulation and hyaline membrane disease . Lancet 2:170, 1968;.
8 +
Stark CR, Abramson D, Erkan V:  Intravascular coagulation and hyaline membrane disease . Lancet 2:520, 1968;.
9 +
Hathaway WE, Mull NN, Pechet GS:  Disseminated intravascular coagulation in the newborn . Pediatrics 43:233-238, 1969;.
10 +
Stiehm ER, Clatanoff DV:  Split products of fibrin in the serum of newborns . Pediatrics 43:770-780, 1969;. 1
11 +
Biggs R, Macfarlane RG:  Quantitative test for factor V deficiency , in Human Blood Coagulation . Oxford, Basil Blackwell & Mott Ltd, 1962;, p 288.
12 +
Poole JG, Robinson J:  Assay of plasma antihemophilic globulin (AHG) . Br J Haematol 5:17-23, 1959;.
13 +
Merskey C, Lalezari P, Johnson AJ:  A rapid, simple sensitive method for measuring fibrinolytic split products in human serum . Proc Soc Exp Biol Med 131:871-875, 1969;.
14 +
Breen FA, Tullis JL:  Ethanol gelation test improved . Ann Intern Med 71:433, 1969;.
15 +
Bleyer WA, Hakami N, Shepard TH:  The development of hemostasis in the human fetus and newborn infant . J Pediatr 79:838-853, 1971;.
16 +
Markarian M, et al:  Hypercoagulability in premature infants with special reference to the respiratory distress syndrome and hemorrhage: I. Coagulation studies . Biol Neonate 17:84-97, 1971;.
17 +
Markarian M, et al:  Hypercoagulability in premature infants with special reference to the respiratory distress syndrome and hemorrhage: II. The effect of heparin . Biol Neonate 17:98-111, 1971;.
18 +
McKay DG:  Progress in Disseminated Intravascular Coagulation . Calif Med 111:186-199, 279-290, 1969;.

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