We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Clinical Significance of Tyrosinemia of Prematurity

Irwin J. Light, MD; James M. Sutherland, MD; Helen K. Berry, MA
Am J Dis Child. 1973;125(2):243-247. doi:10.1001/archpedi.1973.04160020067013.
Text Size: A A A
Published online


The clinical effects of transient elevation of serum tyrosine level were evaluated in a group of premature infants. Neurologic performance was measured at 15 to 29 months of age using the Bayley Infant Scale of Mental Development. There were no differences in either motor or mental development as measured by this test between infants with high and low serum tyrosine levels.

The neonatal course in infants with elevated serum tyrosine levels was compared to that in two groups of infants with low serum tyrosine levels: one group with and one without supplemental ascorbic acid. The only difference in the occurrence of maternal or neonatal complications was in the group with high tyrosine levels, which had significantly greater incidence of symptoms similar to those in infants with neonatal sepsis and characterized by lethargy, poor feeding, and failure to gain weight.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.