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Immunity to Measles in Children Vaccinated Before and After 1 Year of Age

David W. Reynolds, MD; Armand Start, MD
Am J Dis Child. 1972;124(6):848-850. doi:10.1001/archpedi.1972.02110180050006.
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Humoral immunity to measles was studied in a group of children vaccinated before and a group vaccinated after their first birthday in the same office practice. All received live attenuated measles vaccine with measles immune globulin (MIG). The average postvaccination interval was five years. A significantly higher percentage of those vaccinated before 12 months of age were without detectable hemagglutination-inhibition antibody. Excessive dosage of MIG was not a significant factor in determining the lack of immune response. Revaccination of 12 seronegative children elicited an anamnestic antibody response in seven. The adjusted seroconversion rates, considering the anamnestic response to revaccination, were 79% and 100% for children vaccinated before and after their first birthday, respectively. These data support the recent recommendation that all children vaccinated before 9 to 10 months of age be routinely revaccinated.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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