Cortisol Secretion in Acidotic and Nonacidotic Diabetes Mellitus FREE

Mark A. Sperling, MB, MRACP; George Bacon, MD; Frederick M. Kenny, MD; Allan L. Drash, MD

Received for publication March 3, 1972; accepted May 22.

Reprint requests to Department of Pediatrics, Harbor General Hospital, 1000 W Carson St, Torrance, Calif 90509 (Dr. Sperling).

Am J Dis Child. 1972;124(5):690-692. doi:10.1001/archpedi.1972.02110170068009.

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

Acute changes in adrenocortical function were assessed by a method which permits simultaneous determination of cortisol and short-term cortisol secretion rates from specific activities in serum. Four children were studied during the first two hours of their initial hospitalization for impending ketoacidosis. Three were acidotic (plasma bicarbonate [unk] 19 mEq/liter); two of these were restudied one week later following stabilization of their disease. In all six studies cortisol secretion rate was directly correlated to the degree of acidosis (r =.96), being high in the presence of, but normal in the absence or following correction of, acidosis. These studies document the magnitude of adrenal response to the stress of diabetic ketoacidosis. The consistent presence of normal cortisol secretion rate in diabetic children without acidosis argues against the contention that increased cortisol secretion is a factor in the pathogenesis of juvenile diabetes mellitus.

REFERENCES

ABSTRACT | REFERENCES

Bookman JJ, Drachman SR, Schaefer LE, et al: Steroid diabetes in man: The development of diabetes during treatment with cortisone and corticotropin . Diabetes 2:100-111, 1953;.

Conn JW, Fajans SS: Influence of adrenal cortical steroids in carbohydrate metabolism in man . Metabolism 5:114-127, 1956;.

Boshell BR, Chaudalia HB: Hormonal interrelationships , in Ellenberg M, Rifkin H (eds): Diabetes Mellitus: Theory and Practice . New York, McGraw Hill Book Co Inc, 1970;, pp 96-111.

Rifkin HS, Solomon S, Lieberman S: Adrenal cortical function in diabetic retinopathy and nephropathy . Diabetes 7:9-14, 1958;.

Lentle BC, Thomas JP: Adrenal function and the complications of diabetes . Lancet 2:544-549, 1964;.

Garces LY, Kenny FM, Drash A, et al: Cortisol secretion in acidotic and non-acidotic juvenile diabetes mellitus . J Pediat 74:517-522, 1969;.

Petersen RE, Wyngaarden JB: The miscible pool and turnover rate of hydrocortisone in man . J Clin Invest 35:552-561, 1956;.

Murphy BEP: Some studies of the protein binding of steroids and their application to the routine micro and ultra-micro measurement of various steroids in body fluids by competitive protein-binding radioassay . J Clin Endocr 27:973-990, 1967;.

Kenny FM, Malvaux D, Migeon CJ: Cortisol production rates in newborn babies, older infants and children . Pediatrics 31:360-373, 1963;.

Pfeiffer EF: Recognized diabetogenic hormones and diabetes in man , in Leibel BS, Wrenshall GA (eds): On the Nature and Treatment of Diabetes . Amsterdam, Excerpta Medica Foundation, 1965;, pp 368-386.

McArthur JW, Smart GA, McLachlan EA, et al: Studies concerning the role of adrenal cortex in the pathologic physiology of diabetic acidosis: Temporal relations between the metabolic events of experimental diabetic acidosis and the level of adrenocortical function . J Clin Invest 33:420-436, 1954;.

Wieland RE, Schachner SH, Kruger FA, et al: False elevation of plasma 17-OHCS in diabetic ketosis . Diabetes 14:744-745, 1965;.

Klein R, Weigand FA, Iunnes M, et al: Corticoids in serum of children with treated diabetes mellitus . Pediatrics 17:214-220, 1956;.

Lundquist I, Norden A, Schersten B: Studies in subjects with positive postprandial clinistix (R) test . Acta Med Scand 187:163-168, 1970;.

Espiner EA, Beaven DW: Cortisol metabolism in diabetes mellitus . Clin Sci 24:383-389, 1963;.

Hellman L, Fujimori N, Curti J, et al: Cortisol is secreted episodically by normal man . J Clin Endocr 30:411-422, 1970;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal