Rubella surveillance was provided for two groups of adolescent girls in Cincinnati. Both the Princeton School District (PSD) group and the Adolescent Clinic (AC) group were similar in age but different in racial composition, socioeconomic level, and experience with pregnancy. Rubella susceptibility, using the hemagglutination-inhibition antibody test, was 26% for the PSD group and 14% for the AC group. The PSD girls were nulliparous and were immunized without a contraceptive program. Parous and sexually active nulliparous girls in the AC were immunized while concurrently using contraception. Medroxyprogesterone acetate suspension was used as a contraceptive for those AC girls who needed short-term contraception following immunization or who could not adjust well to oral contraception or to an intrauterine device.