The authors have brought to date the changing scene in the enigmatic disease known as osteomyelitis. Their record review of 248 patients observed at the Massachusetts General Hospital between the years 1963 and 1966 shows a marked reduction in the incidence of hematogenous bone infections of the young during the era of more effective antimicrobial therapy. They found a higher incidence of the disease due to contiguous infection (frequently about metallic devices for bone fixation) and secondary to vascular insufficiency. Noted is an impressive shift away from the common causative organisms recorded in the literature of a generation ago and instances of osteomyelitis due to unusual infective agents. The book ineludes a pertinent discussion of the pathophysiology of the disease in the light of recent studies.