Immune Response in Patients Who Received Blood Containing Serum Hepatitis Antigen FREE

Alfred M. Prince, MD; Betsy Brotman; Charles E. Cherubin, MD

[+] Author Affiliations

Reprint requests to New York Blood Center, 310 E 67th St, New York 10021 (Dr. Prince).

Am J Dis Child. 1972;123(4):415-418. doi:10.1001/archpedi.1972.02110100147057.

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ABSTRACT

ABSTRACT | REFERENCES

Conventional methods for detection of SH (Australia antigen, HAA) antigen and corresponding antibody, such as agar gel diffusion (AGD), immunoelectroosmophoresis (IEOP), and complement fixation (CF), have failed to incriminate hepatitis virus type B in a major portion of cases of posttransfusion hepatitis.^1,2 It has not been possible to determine whether this reflects only the inadequate sensitivity of these assay methods or whether these findings reflect the role of other viruses, lacking an association of the SH antigen, in the etiology of posttransfusion hepatitis. It has been recognized that introduction of more sensitive methods, such as radioimmune assay³ or hemagglutination inhibition (HAI)⁴ may provide an answer. We report an investigation of patterns of immune response as shown by passive HA technique in 35 patients inadvertently transfused with blood containing SH antigen. Serological evidence of infection with hepatitis virus type B has been obtained in 34 of the 35

REFERENCES

ABSTRACT | REFERENCES

Purcell RH, Holland PV, Walsh JH, et al: A complement fixation technique for measuring Australia antigen and antibody . J Infect Dis 120:383-386, 1969;.

Prince AM, Szmuness W, Millian SJ, et al: A serological study of cytomegalovirus infections associated with blood transfusions . New Eng J Med 284:1125-1131, 1971;.

Walsh JH, Yalow RS, Berson SA: Detection of Australia antigen and antibody by means of radioimmuno assay techniques . J Infect Dis 121:550-554, 1970;.

Vyas GN, Shulman NR: Hemagglutination assay for antigen and antibody associated with viral hepatitis . Science 170:332-333, 1970;.

Prince AM: An antigen detected in the blood during the incubation period of serum hepatitis . Proc Nat Acad Sci 60:814-821, 1968;.

Prince AM, Burke K: Serum hepatitis antigen (SH): Rapid detection by high voltage immunoelectroosmophoresis . Science 169:593-595, 1970;.

Prince AM, Szmuness W, Wood KR, et al: Antibody against serum hepatitis antigen: Prevalence and potential use as an immune serum globulin in prevention of serum hepatitis infections . New Eng J Med 285:933-938, 1971;.

Wroblewski F, LaDue JS: Serum glutamic pyruvic transaminase in cardiac and hepatic disease . Proc Soc Exp Biol Med 91:571-576, 1956;.

Gocke DJ, Kavey NB: Hepatitis antigen: Correlation with disease and infectivity of blood donors . Lancet 2:1055-1057, 1969;.

Lander JJ, Giles JP, Purcell RH, et al: Viral hepatitis, type B (MS-2 strain): Detection of antibody after primary infection . New Eng J Med 285:303-307, 1971;.

Holland RV, Walsh JH, Morrow AG, et al: Failure of Australia antibody to prevent post-transfusion hepatitis . Lancet 2:553-555, 1969;.

Greenberg HB, Gocke DJ: An analysis of antibody response to Australia antigen in man . J Infect Dis 123:356-364, 1971;.

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