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April 1972, Vol 123, No. 4 >
Article | April 1972

Epidemiological Study of Type B Hepatitis in Communities FREE

Victoria Drouhet, MD
[+] Author Affiliations

Reprint requests to SESEP, Department of Virology, International Children's Center, Bois de Boulogne, 75-Paris 16, France (Dr. Drouhet).


Am J Dis Child. 1972;123(4):368-373. doi:10.1001/archpedi.1972.02110100100036.
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References
Comments

The discovery by Blumberg et al in 1967 of the association between Australia (Au) antigen and viral hepatitis1 introduced a serological test of value in diagnosis. It now seems certain that this antigen is more specifically associated with serum hepatitis, as Prince2 demonstrated in 1968 and Giles et al3 in 1969. Moreover, the transmission of serum hepatitis by the oral route has been confirmed by the experiments of Krugman and Giles4 in 1970. We studied sporadic cases of viral hepatitis in hospitalized children and adults and observed cases in closed communities (a preventorium and two sanatoriums), where the long stay facilitated epidemiological study.

Materials and Methods  We examined sera from 315 hospitalized patients (210 children, 105 adults). Although the main focus of the study was viral hepatitis, in order to obtain specimens of sera at the onset of the disease, we obtained specimens in all cases of

REFERENCES

1 +
Blumberg BS, Gerstley BJS, Hungerford DA, et al:  A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis . Arch Intern Med 66:924-931, 1967;.
2 +
Prince AM:  An antigen detected in the blood during the incubation period of serum hepatitis . Proc Nat Acad Sci USA 60:814-821, 1968;.
3 +
Giles GL, McCollum RV, Berndtson LW, et al:  Viral hepatitis: Relation of Australia/SH antigen to the Willowbrook strain . New Eng J Med 281:119-122, 1969;.
4 +
Krugman S, Giles JP:  Viral hepatitis: New light on old disease . JAMA 212:1019-1029, 1970;:
5 +
Prince AM:  The high voltage immunoelectroosmophoretic (IEOP) technique for detection of SH antigen: Application to blood donor screening and to study of liver disease . Vox Sang 19:205-210, 1970;.
6 +
Soulier JP, Courouce-Pauty AM, Benamon-Djlane D:  Étude immunologique des hépatites a virus: Recherche de l' antigéne Australie et de l' anticorps correspondant: Premiers résultats . Rev Franc Transfus 12:361-384, 1969;.
7 +
Krugman S, Giles JP, Hammond J:  Infectious hepatitis: Evidence of distinctive clinical, epidemiological and immunological types of infections . JAMA 200:365-373, 1967;.
8 +
Alvermann B, Spies K, Puschel J, et al:  Failure to detect Australia Antigen in correspondence to other clinical, epidemiological and laboratory data in children with infectious hepatitis . Vox Sang 19:318-319, 1970;.
9 +
Wewalka F, Gnan F, Krassnitzky O, et al:  Au/SH antigen in liver disease . Vox Sang 19:311-317, 1970;.
10 +
London WT, Sutnick AI, Blumberg BS:  Australia antigen and acute viral hepatitis . Ann Intern Med 70:55-59, 1969;.
11 +
Cossart Y, Taylor PE, Vamrman J, et al:  Australia SH antigen in hepatitis patients in London . Brit Med J 3:5673-5755, 1969;.
12 +
Wright R, McCollum RW, Klatstein G:  Australia antigen in acute and chronic liver disease . Lancet 2:118-124, 1969;.
13 +
Gocke DJ, Kavey NB:  Hepatitis antigen: Correlation with disease and infectivity of blood donors . Lancet 1:1055-1059, 1969;.
14 +
Costantino D, Del Prete S, Doglia M:  Experiences on Australia antigen in Italy . Vox Sang 19:394-400, 1970;.
15 +
Kaboth U, Gallasch E, Verma P, et al: Australia-Antigen (SH Antigen) bei Blutspenderm und Leberkranken in Raum Gottingen. Verh Deutsch Ges Med, to be published.
16 +
Schizas N, Mandalki T, Achimastos J, et al:  Some observations on the Australia antigen , in Proceedings, VI Kongress der Weltfoderation fur Haemophilie . Baden, Germany, 1970;.
17 +
Blumberg BS, Sutnick AI, London T:  Australia antigen as a hepatitis virus . JAMA 48:1-8, 1970;.
18 +
Yeuglaiwaha C, Goudie RB, Goldberg DM, et al:  Australia antigen in west of Scotland and north of England . Lancet 2:121-123, 1970;.
19 +
Lous P, Skinhøj P, Olesen H:  HAA antigen determination in 12,000 patients in a general Copenhagen hospital . Vox Sang 19:379-383, 1970;.
20 +
Robinet-Levy M, Lemaire JM:  L' antigéne Australia chez les sujets apparemment sains . J Med Montpellier 5:480-482, 1970;.
21 +
Lesobre R, Ruffino J, Teyssier L, et al:  Les ictéres au cours du traitement par la rifampicine . Rev Tuberc 33:393-403, 1969;.
22 +
Morere P, Bourreille J, Matray F, et al:  Etude des fonctions hépatiques chez les malades traités par la rifampicine . Rev Tuberc 34:403-414, 1970;.
23 +
Oury M, Tuchais E, Tuchais M:  Epidémiologie des ictéres dans un service de phtisiologie: Responsabilité de la rifampicine . Rev Tuberc 34:415-484, 1970;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Blumberg BS, Gerstley BJS, Hungerford DA, et al:  A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis . Arch Intern Med 66:924-931, 1967;.
2 +
Prince AM:  An antigen detected in the blood during the incubation period of serum hepatitis . Proc Nat Acad Sci USA 60:814-821, 1968;.
3 +
Giles GL, McCollum RV, Berndtson LW, et al:  Viral hepatitis: Relation of Australia/SH antigen to the Willowbrook strain . New Eng J Med 281:119-122, 1969;.
4 +
Krugman S, Giles JP:  Viral hepatitis: New light on old disease . JAMA 212:1019-1029, 1970;:
5 +
Prince AM:  The high voltage immunoelectroosmophoretic (IEOP) technique for detection of SH antigen: Application to blood donor screening and to study of liver disease . Vox Sang 19:205-210, 1970;.
6 +
Soulier JP, Courouce-Pauty AM, Benamon-Djlane D:  Étude immunologique des hépatites a virus: Recherche de l' antigéne Australie et de l' anticorps correspondant: Premiers résultats . Rev Franc Transfus 12:361-384, 1969;.
7 +
Krugman S, Giles JP, Hammond J:  Infectious hepatitis: Evidence of distinctive clinical, epidemiological and immunological types of infections . JAMA 200:365-373, 1967;.
8 +
Alvermann B, Spies K, Puschel J, et al:  Failure to detect Australia Antigen in correspondence to other clinical, epidemiological and laboratory data in children with infectious hepatitis . Vox Sang 19:318-319, 1970;.
9 +
Wewalka F, Gnan F, Krassnitzky O, et al:  Au/SH antigen in liver disease . Vox Sang 19:311-317, 1970;.
10 +
London WT, Sutnick AI, Blumberg BS:  Australia antigen and acute viral hepatitis . Ann Intern Med 70:55-59, 1969;.
11 +
Cossart Y, Taylor PE, Vamrman J, et al:  Australia SH antigen in hepatitis patients in London . Brit Med J 3:5673-5755, 1969;.
12 +
Wright R, McCollum RW, Klatstein G:  Australia antigen in acute and chronic liver disease . Lancet 2:118-124, 1969;.
13 +
Gocke DJ, Kavey NB:  Hepatitis antigen: Correlation with disease and infectivity of blood donors . Lancet 1:1055-1059, 1969;.
14 +
Costantino D, Del Prete S, Doglia M:  Experiences on Australia antigen in Italy . Vox Sang 19:394-400, 1970;.
15 +
Kaboth U, Gallasch E, Verma P, et al: Australia-Antigen (SH Antigen) bei Blutspenderm und Leberkranken in Raum Gottingen. Verh Deutsch Ges Med, to be published.
16 +
Schizas N, Mandalki T, Achimastos J, et al:  Some observations on the Australia antigen , in Proceedings, VI Kongress der Weltfoderation fur Haemophilie . Baden, Germany, 1970;.
17 +
Blumberg BS, Sutnick AI, London T:  Australia antigen as a hepatitis virus . JAMA 48:1-8, 1970;.
18 +
Yeuglaiwaha C, Goudie RB, Goldberg DM, et al:  Australia antigen in west of Scotland and north of England . Lancet 2:121-123, 1970;.
19 +
Lous P, Skinhøj P, Olesen H:  HAA antigen determination in 12,000 patients in a general Copenhagen hospital . Vox Sang 19:379-383, 1970;.
20 +
Robinet-Levy M, Lemaire JM:  L' antigéne Australia chez les sujets apparemment sains . J Med Montpellier 5:480-482, 1970;.
21 +
Lesobre R, Ruffino J, Teyssier L, et al:  Les ictéres au cours du traitement par la rifampicine . Rev Tuberc 33:393-403, 1969;.
22 +
Morere P, Bourreille J, Matray F, et al:  Etude des fonctions hépatiques chez les malades traités par la rifampicine . Rev Tuberc 34:403-414, 1970;.
23 +
Oury M, Tuchais E, Tuchais M:  Epidémiologie des ictéres dans un service de phtisiologie: Responsabilité de la rifampicine . Rev Tuberc 34:415-484, 1970;.

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