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April 1972, Vol 123, No. 4 >
Article | April 1972

What Is Australia Antigen? FREE

Yvonne E. Cossart, MB, BSc, MRC Path, DCP
[+] Author Affiliations

Reprint requests to Virus Reference Laboratory, Central Public Health Laboratory, Colindale Ave, London, NW9 5HT, England (Dr. Cossart).


Am J Dis Child. 1972;123(4):321-322. doi:10.1001/archpedi.1972.02110100053021.
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References
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When negatively stained preparations of Australia antigen are examined in the electron microscope, three types of particle can be distinguished. The most plentiful are approximately spherical and about 160 to 220 angstroms in diameter. Substructure is difficult to find, but the appearance suggests that the particles are built up of a number of identical subunits.1

Long particles are also seen in most instances. These have about the same diameter as the small spherical particles but vary greatly in length from bacilliform or ovoid structures to long filamentous ones. Some have expanded ends, some are bent at sharp angles, and many exhibit cross-striations which have a periodicity of 35 A.2

The third particle type is the double-shelled or "doughnut" form which is about 450 A in diameter and consists of a central core which is sometimes penetrated by the stain, surrounded by a shell which also seems to be

REFERENCES

1 +
Bauer ME, Blumberg BS, Werner B:  Particles associated with the Australia antigen in the sera of patients with leukemia, Downs' syndrome and hepatitis . Nature 218:1057-1059, 1968;.
2 +
Almeida JD, Zuckerman AJ, Taylor PE, et al:  Immune electron microscopy of the Australia-SH (serum hepatitis) antigen . Microbios 1:117-123, 1970;.
3 +
Dane DS, Cameron CH, Briggs M:  Virus-like particles in sera of patients with Australia antigen-associated-hepatitis . Lancet 1:695-698, 1970;.
4 +
Cossart YE, Field AM:  Virus-like particles in the sera of patients with Australia antigen-associated-hepatitis . Lancet 1:848, 1970;.
5 +
Jozwiak W, Koscielak J, Madalinski K, et al:  RNA of Australia antigen . Nature 229:92-94, 1971;.
6 +
Barker LF, Shulman NR, Murray R, et al:  Transmission of serum hepatitis . JAMA 211:1509-1512, 1970;.
7 +
Bancroft JB, Hiebert E, Bracker CE:  The effects of various polyanions on shell formation of some spherical viruses . Virology 39:924-930, 1969;.
8 +
Bancroft JB, Hiebert E, Rees MN, et al:  Properties of cowpea chlorotic mottle virus: Its protein and nucleic acid . Virology 34:224-235, 1968;.
9 +
Hull R, Hills GJ, Markham K:  Studies on alfalfa mosaic virus: II. The structure of the virus components . Virology 37:416-428, 1969;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Bauer ME, Blumberg BS, Werner B:  Particles associated with the Australia antigen in the sera of patients with leukemia, Downs' syndrome and hepatitis . Nature 218:1057-1059, 1968;.
2 +
Almeida JD, Zuckerman AJ, Taylor PE, et al:  Immune electron microscopy of the Australia-SH (serum hepatitis) antigen . Microbios 1:117-123, 1970;.
3 +
Dane DS, Cameron CH, Briggs M:  Virus-like particles in sera of patients with Australia antigen-associated-hepatitis . Lancet 1:695-698, 1970;.
4 +
Cossart YE, Field AM:  Virus-like particles in the sera of patients with Australia antigen-associated-hepatitis . Lancet 1:848, 1970;.
5 +
Jozwiak W, Koscielak J, Madalinski K, et al:  RNA of Australia antigen . Nature 229:92-94, 1971;.
6 +
Barker LF, Shulman NR, Murray R, et al:  Transmission of serum hepatitis . JAMA 211:1509-1512, 1970;.
7 +
Bancroft JB, Hiebert E, Bracker CE:  The effects of various polyanions on shell formation of some spherical viruses . Virology 39:924-930, 1969;.
8 +
Bancroft JB, Hiebert E, Rees MN, et al:  Properties of cowpea chlorotic mottle virus: Its protein and nucleic acid . Virology 34:224-235, 1968;.
9 +
Hull R, Hills GJ, Markham K:  Studies on alfalfa mosaic virus: II. The structure of the virus components . Virology 37:416-428, 1969;.

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