The majority of patients with clinically recognizable virus hepatitis recover. Varying degrees of liver damage persists in a few. However, the lack of knowledge of factors responsible for the persistence of the stimulates continued interest in the sequelae of hepatitis.
The different forms of chronic hepatitis,1-3 the normal course of hepatitis,4,5 and the prolonged forms6-9 must be defined. Chronic hepatitis is now classified from the pathological point of view as chronic persistent hepatitis and chronic aggressive hepatitis.10 The latter is divided into a moderate and a more aggressive form. Chronic persistent hepatitis is characterized by lymphoid cell infiltration of portal tracts, sometimes with slight fibrosis, but sharp border lines of lobules and normal liver architecture. The main complaint is fatigue. In some cases there are no clinical signs of illness. Slight enlargement of the liver is present, transaminase values are elevated, sulfobromophthalein (Bromsulphalein [BSP]) retention is