0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

THE 4p—SYNDROME

JOHN W. MACE, MD; M.D. CUNNINGHAM, MD
Am J Dis Child. 1972;123(3):264. doi:10.1001/archpedi.1972.02110090134026.
Text Size: A A A
Published online

To the Editor.—We enjoyed the recent article by Guthrie and associates on "The 4p—Syndrome".1 We should like to point out, however, that they, as did Miller et al2 and Falk,3 noted the clinical similarity of the cri du chat (5p—syndrome) to the 4p—syndrome but failed to mention the Smith-Lemli-Opitz syndrome in the differential diagnosis. Nearly all of the common features of the 4p—syndrome listed in Fig 31 p 424 of their article are also common features of the Smith-Lemli-Opitz syndrome.4,5 We have not found enough differentiating features between these syndromes to allow for clinical separation but feel one must rely on chromosomal analysis to make this distinction.6

It is true that colobomata of the iris, midline scalp defects, and low finger ridge counts are more commonly seen in the 4p—syndrome and pedal syndactyly, ptosis of the eyelids, and

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

* * SCHEDULED MAINTENANCE * *

Our websites may be periodically unavailable between midnight and 04:00 ET Thursday, July 10th, for regularly scheduled maintenance.

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();