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Article |

Compliance Dose-Response Relationships in Streptococcal Pharyngitis

Virgil M. Howie, MD; John H. Ploussard, MD
Am J Dis Child. 1972;123(1):18-25. doi:10.1001/archpedi.1972.02110070068006.
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Two clinical trials of five forms of two antibiotics in the treatment of streptococcal pharyngitis were undertaken in an attempt to relate bacteriologic outcomes to amounts of drug actually consumed. All antibiotics were prescribed in suspension form and daily intakes were calculated and averaged for both the first and second five days of treatment. A simple method for quantifying drug intake, which involves weighing medicine bottles before, during, and after therapy, was used. The wide range of ingested doses observed in 312 private patients explain most of the different results from similar prescribed doses in our practices.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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