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Article |

Dissociation of Erythroblastic and Myeloblastic Proliferation in Erythroleukemia

James N. Roloff; John N. Lukens, MD
Am J Dis Child. 1972;123(1):11-13. doi:10.1001/archpedi.1972.02110070061004.
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The concept of malignancy of the erythron was reexamined by characterization of erythropoiesis in a 6-year-old boy with erythroleukemia. Erythroblastic and myeloblastic activities were monitored with bone marrow and peripheral blood examinations at three-to four-week intervals for 21 months. Fluctuations in myeloblastic proliferation bore no relationship to the profile of erythroid proliferation. In contrast, a direct relationship between severity of anemia and magnitude of erythroid hyperplasia was demonstrated, and a physiologic relationship between serum erythropoietin and the hemoglobin concentration was observed. Though qualitatively abnormal, erythropoiesis in erythroleukemia is regulated by physiologic control mechanisms.

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