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December 1971, Vol 122, No. 6 >
Article | December 1971

Cardiac Studies of Infant Twins With Marfan's Syndrome FREE

Arno R. Hohn, MD; Hazel M. Webb, MD
[+] Author Affiliations

Received for publication May 3, 1971; accepted July 13.

Reprint requests to 80 Barre St, Charleston, SC 29401 (Dr. Hohn).


Am J Dis Child. 1971;122(6):526-528. doi:10.1001/archpedi.1971.02110060096017.
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The pathologic manifestations of Marfan's syndrome may appear in early infancy as indicated by the hemodynamic and angiocardiographic findings in 5-month-old twins. Mitral insufficiency represented the major cardiovascular malformation. This was shown to be due to elongated chordae tendineae and elongation with redundance of the anterior leaflet of the mitral valves in both of the twins at autopsy. Dilatation of the aortic sinuses of Valsalva and pulmonary trunk were also seen. Reports of the occurrence of the syndrome, a Mendelian dominant trait, in identical twins have been surprisingly infrequent.

REFERENCES

1 +
Keith JD, Rowe RD, Vlad P: Heart Disease in Infancy and Childhood , ed 2. New York, Macmillan Co, 1967;, pp 1160-1170.
2 +
McKusick VA:  The cardiovascular aspects of Marfan's syndrome: A heritable disorder of connective tissue . Circulation 11( (suppl 3) ):321-342, 1955;.
Link to Article
3 +
Bowers D:  Pathogenesis of primary abnormalities of the mitral valve in Marfan's syndrome . Brit Heart J 31:676-678, 1969;.
Link to Article
4 +
Raghib G, Jue KL, Anderson RC, et al:  Marfan's syndrome with mitral insufficiency . Amer J Cardiol 16:127-131, 1965;.
Link to Article
5 +
Simpson JW, Nora JJ, McNamara DG:  Marfan's syndrome and mitral valve disease . Amer Heart J 77:96-99, 1969;.
Link to Article
6 +
Shankar KR, Hultgren MK, Lauer RM, et al:  Lethal tricuspid and mitral regurgitation in Marfan's syndrome . Amer J Cardiol 20:122-128, 1967;.
Link to Article
7 +
Papaioannou AC, Agustsson MH, Gasul BM:  Early manifestations of the cardiovascular disorders in Marfan's syndrome . Pediatrics 27:255-268, 1961;.
8 +
McKusick VW: Heritable Disorders of Connective Tissue , ed 3. St. Louis, CV Mosby Co, 1966;, pp 38-149.
9 +
Steinberg I, Mangiardi JL, Noble WB:  Aneurysmal dilatation of the aortic sinuses in Marfan's syndrome . Circulation 16:368-373, 1957;.
Link to Article

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Keith JD, Rowe RD, Vlad P: Heart Disease in Infancy and Childhood , ed 2. New York, Macmillan Co, 1967;, pp 1160-1170.
2 +
McKusick VA:  The cardiovascular aspects of Marfan's syndrome: A heritable disorder of connective tissue . Circulation 11( (suppl 3) ):321-342, 1955;.
Link to Article
3 +
Bowers D:  Pathogenesis of primary abnormalities of the mitral valve in Marfan's syndrome . Brit Heart J 31:676-678, 1969;.
Link to Article
4 +
Raghib G, Jue KL, Anderson RC, et al:  Marfan's syndrome with mitral insufficiency . Amer J Cardiol 16:127-131, 1965;.
Link to Article
5 +
Simpson JW, Nora JJ, McNamara DG:  Marfan's syndrome and mitral valve disease . Amer Heart J 77:96-99, 1969;.
Link to Article
6 +
Shankar KR, Hultgren MK, Lauer RM, et al:  Lethal tricuspid and mitral regurgitation in Marfan's syndrome . Amer J Cardiol 20:122-128, 1967;.
Link to Article
7 +
Papaioannou AC, Agustsson MH, Gasul BM:  Early manifestations of the cardiovascular disorders in Marfan's syndrome . Pediatrics 27:255-268, 1961;.
8 +
McKusick VW: Heritable Disorders of Connective Tissue , ed 3. St. Louis, CV Mosby Co, 1966;, pp 38-149.
9 +
Steinberg I, Mangiardi JL, Noble WB:  Aneurysmal dilatation of the aortic sinuses in Marfan's syndrome . Circulation 16:368-373, 1957;.
Link to Article

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