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October 1971, Vol 122, No. 4 >
Article | October 1971

Maximum Daily Intake of Lead Without Excessive Body Lead-Burden in Children FREE

Barry G. King, PhD
[+] Author Affiliations

Received for publication May 19, 1971; accepted July 16.

Members of the ad hoc committee who assisted in the development of the proposed daily permissible intake were Roger Challop, MD, Bureau of Community Environmental Management, Department of Health, Education and Welfare (DHEW); Julian Chisolm, MD, Johns Hopkins University Medical School; Jane Lin-Fu, MD, Maternal and Child Health Service, DHEW; Herbert Stokinger, PhD, Bureau of Occupational Safety and Health, DHEW; Herbert Stokinger, PhD, Bureau of Occupational Safety and Health, DHEW; Lloyd Tepper, MD, Kettering Laboratory, Cincinnati; Barry G. King, PhD, Committee Chairman, Bureau of Community Environmental Management, DHEW.

Reprint requests to Room 8004, Federal Building 550 Main St, Cincinnati 45202 (Dr. King).


Am J Dis Child. 1971;122(4):337-340. doi:10.1001/archpedi.1971.02110040121011.
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Comments

Three hundred micrograms of elemental lead is considered to be the maximum daily permissible intake (DPI) from all sources for children. As the average intake increases above this value, the entire amount cannot be excreted and accumulation in the body begins. This will increase progressively as long as undue ingestion continues. The DPI has been established on the basis of levels of lead in the blood of nonexposed and exposed children including those with frank lead poisoning; results of experimental lead ingestion by adults; fecal lead output in children; initial biologic effects of increased lead intake; rates of increase in lead in the blood of exposed children, and sequelae of lead poisoning. The aim of the DPI is prevention of disease and preservation of health in children.

REFERENCES

1 +
Steinfeld JL: Surgeon General's Policy Statement on Medical Aspects of Childhood Lead Poisoning . Public Health Service, 1970;.
2 +
Robinson NJ, Karpinski FE, Brieger H:  The concentration of lead in plasma, whole blood and erythrocytes of infants and children . Pediatrics 21:793-797, 1958;.
3 +
Haggerty CJ, Norland RA: An inquiry into Certain Aspects of Lead Poisoning in Children as a Community Problem . Department of Pediatrics report, Marquette Medical School, 1969;.
4 +
Tepper LB: Statement before the DPI ad hoc committee meeting, Cincinnati, 1971.
5 +
Kehoe RA:  Harben Lectures . J Roy Inst Public Health 24:81-97, 101, 129-143, 177-203, 1961;.
6 +
Chisolm JJ Jr, Harrison HE:  The exposure of children to lead . Pediatrics 18:943-957, 1956;.
7 +
Barltrop D, Killala NJP:  Fecal excretion of lead by children . Lancet 2:1017-1019, 1967;.
8 +
Chisolm JJ: Statement before the DPI ad hoc committee meeting, Cincinnati, 1971.

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References

1 +
Steinfeld JL: Surgeon General's Policy Statement on Medical Aspects of Childhood Lead Poisoning . Public Health Service, 1970;.
2 +
Robinson NJ, Karpinski FE, Brieger H:  The concentration of lead in plasma, whole blood and erythrocytes of infants and children . Pediatrics 21:793-797, 1958;.
3 +
Haggerty CJ, Norland RA: An inquiry into Certain Aspects of Lead Poisoning in Children as a Community Problem . Department of Pediatrics report, Marquette Medical School, 1969;.
4 +
Tepper LB: Statement before the DPI ad hoc committee meeting, Cincinnati, 1971.
5 +
Kehoe RA:  Harben Lectures . J Roy Inst Public Health 24:81-97, 101, 129-143, 177-203, 1961;.
6 +
Chisolm JJ Jr, Harrison HE:  The exposure of children to lead . Pediatrics 18:943-957, 1956;.
7 +
Barltrop D, Killala NJP:  Fecal excretion of lead by children . Lancet 2:1017-1019, 1967;.
8 +
Chisolm JJ: Statement before the DPI ad hoc committee meeting, Cincinnati, 1971.

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