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September 1971, Vol 122, No. 3 >
Article | September 1971

A Teething Lotion Resulting in the Misdiagnosis of Diphenylhydantoin Administration FREE

M. Douglas Jones, MD; Ray E. Helfer, MD
[+] Author Affiliations

Received for publication Dec 12, 1969; accepted April 12, 1971.

Reprint requests to the Department of Pediatrics, Brooke Army Medical Center, Fort Sam Houston, Texas 78234 (Dr. Jones).


Am J Dis Child. 1971;122(3):259-260. doi:10.1001/archpedi.1971.02110030117021.
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Comments

Constituents of a commercial teething preparation (Dr. Hand's teething lotion) are absorbed and can interfere markedly with measurement of serum diphenylhydantoin levels by the method of Svensmark and Kristensen.

REFERENCES

1 +
Svensmark C, Kristensen P:  Determination of diphenylhydantoin and phenobarbital in small amounts of serum . J Lab Clin Med 61:501-507, 1963;.
2 +
Dill WA, Kazenko A, Wolf LM, et al:  Studies of 5.5-diphenylhydantoin (Dilantin) in animals and man . J Pharmacol Exp Ther 118:270-279, 1956;.
3 +
Kristensen M, Hansen JM, Hansen OE, et al:  Sources of error in the determination of phenytoin (Dilantin) by Svensmark and Kristensen's method . Acta Neurol Scand 43:447-450, 1967;.

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References

1 +
Svensmark C, Kristensen P:  Determination of diphenylhydantoin and phenobarbital in small amounts of serum . J Lab Clin Med 61:501-507, 1963;.
2 +
Dill WA, Kazenko A, Wolf LM, et al:  Studies of 5.5-diphenylhydantoin (Dilantin) in animals and man . J Pharmacol Exp Ther 118:270-279, 1956;.
3 +
Kristensen M, Hansen JM, Hansen OE, et al:  Sources of error in the determination of phenytoin (Dilantin) by Svensmark and Kristensen's method . Acta Neurol Scand 43:447-450, 1967;.

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