The occurrence of jaundice in babies seriously ill with bacterial infection is well recognized. This series of 22 newborn infants demonstrates that bacterial infection and jaundice may be associated, without severe constitutional upset and with few abnormal clinical signs or laboratory findings. There were no deaths in this series. Urinary tract infection was present in nine babies. Bacterial infection should be considered as the possible cause of neonatal jaundice, whatever the clinical condition of the baby.