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July 1971, Vol 122, No. 1 >
Article | July 1971

Benignity of Neonatal Tumors and Concept of Cancer Repression in Early Life FREE

Robert P. Bolande, MD
[+] Author Affiliations

Received for publication March 25, 1971; accepted April 12.

Reprint requests to Department of Pathology Children's Hospital of Akron, Buchtel Avenue at Bowery Street, Akron, Ohio 44308 (Dr. Bolande).


Am J Dis Child. 1971;122(1):12-14. doi:10.1001/archpedi.1971.02110010048004.
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Comments

The peculiar benign and regressive pathologic variants of Wilms' tumor and neuroblastoma are emphasized and related to the enhanced survival observed in these tumors when they appear in the newborn or very young infant. There is a tendency toward benignity or regression in other congenital neoplasms such as sacrococcygeal teratoma and congenital leukemia. It is, thus, theorized that specific repressive influences may be maximally exerted on an inborn cancer genome in very early life. Their effect would serve to modify or suppress the full development or progression of malignant disease at this time.

REFERENCES

1 +
Wells HG:  Occurrence and significance of congenital malignant neoplasms . Arch Path 30:535-601, 1940;.
2 +
Bolande RP: Cellular Aspects of Developmental Pathology . Philadelphia, Lea & Febiger, 1967;.
3 +
Everson TC, Cole, WH: Spontaneous Regression of Cancer . Philadelphia, WB Saunders Co, 1966;.
4 +
Bolande RP, Brough AJ, Izant RJ, Jr:  Congenital mesoblastic nephroma of infancy . Pediatrics 40:272-278, 1967;.
5 +
Klapproth HJ:  Wilms' tumor: A report of 45 cases and an analysis of 1,351 cases reported in the world literature from 1940 to 1958 . J Urol 81:633-648, 1959;.
6 +
Favara BE, Johnson W, Ito J:  Renal tumors in the neonatal period . Cancer 22:845-855, 1968;.
7 +
Wigger HJ:  Fetal hamartoma of the kidney . Amer J Clin Path 51:323-337, 1969;.
8 +
Richmond H, Dougall AJ:  Neonatal renal tumors . J Pediat Surg 5:413-418, 1970;.
9 +
Bachmann KD, Kroll W:  Der Wilms-Tumor in Ersten Lebensjahr insbesondere über 62 Nephroblastome des Neugeborenen . Deutsch Med Wschr 94:2598-2601, 1969;.
10 +
Sutow WW, Gehan EA, Heyn RM, et al:  Comparison of survival curves, 1956 versus 1962, in children with Wilms' tumor and neuroblastoma: Report of the Subcommittee on Childhood and Solid Tumors . Pediatrics 45:800-811, 1970;.
11 +
Gross RE, Farber S, Martin LW:  Neuroblastoma sympatheticum: A study and report of 217 cases . Pediatrics 23:1179-1191, 1959;.
12 +
 Survey on neuroblastoma among the surgical fellows of the American Academy of Pediatrics. In conference on the biology of neuroblastoma . J Pediat Surg 3:191-193, 1968;.
13 +
Schneider KM, Becker JM, Krasna IH:  Neonatal neuroblastoma . Pediatrics 36:359-366, 1965;.
14 +
Bachmann KD, Kroll W:  Über das pranatal enstandene. Neuroblastoma sympathicum . Kinderheilk 103:61-72, 1962;.
15 +
Kissane JM, Ackerman LV:  Maturation of tumor of the sympathetic nervous system . J Fac Radiologists 7:109-114, 1955;.
16 +
Haber EL, Bennington JL:  Maturation of congenital extraadrenal neuroblastoma . Arch Path 16:121-125, 1962;.
17 +
Visfeldt J:  Transformation of sympathicoblastoma into ganglioneuroma . Acta Path Microbiol Scand 58:414-428, 1963;.
18 +
Goldman RL, Goldman AN, Winterling CC:  Maturation of tumors of the sympathetic nervous system . Cancer 18:1510-1516, 1965;.
19 +
Dyke PC, Mulkey DA:  Maturation of ganglioneuroblastoma to ganglioneuroma . Cancer 20:1343-1349, 1966;.
20 +
Wilkerson JA, van de Water JM, Goepfert H:  Role of embryonic induction in benign transformation of neuroblastomas . Cancer 20:1335-1342, 1967;.
21 +
Griffin ME, Bolande RP:  Familial neuroblastoma with regression and maturation to ganglioneurofibroma . Pediatrics 43:377-382, 1969;.
22 +
van Erp IFR:  Cutaneous metastases in neuroblastoma . Dermatologica 136:265-269, 1968;.
23 +
Aterman K:  Maturation of neuroblastoma to ganglioneuroma . Amer J Dis Child 120:217-222, 1970;.
24 +
Becker JM: Schneider KM, Krasna IH:  Neonatal neuroblastoma . Progr Clin Cancer 4:382-386, 1970;.
25 +
Coop CE:  Factors affecting survival in neuroblastoma. In conference on the biology of neuroblastoma . J Pediat Surg 3:113-114, 1968;.
26 +
Bolande RP, Towler WF:  A possible relationship of neuroblastoma to von Recklinghausen's disease . Cancer 26:162-175, 1970;.
27 +
Reilly D, Nesbit MD, Krivit W:  Cure of three patients who had skeletal metastases in disseminated neuroblastoma . Pediatrics 41:47-51, 1968;.
28 +
Beckwith JB, Perrin EV:  In situ neuroblastomas: A contribution to the natural history of neural crest tumors . Amer J Path 43:1089-1104, 1963;.
29 +
Guin GH, Gilbert EE, Jones B:  Incidental neuroblastoma in infants . Amer J Clin Path 51:126-135, 1969;.
30 +
Shanklin DR, Sotelo-Avila C:  In situ tumors in fetuses, newborn and young infants . Biol Neonat 14:286-316, 1969;.
31 +
Dillard BM, Mayer JH, McAlister WH, et al:  Sacrococcygeal teratoma in children . J Pediat Surg 5:53-59, 1970;.
32 +
Donnellan WA, Swenson O:  Benign and malignant sacrococcygeal teratomas . Surgery 64:834-846, 1968;.
33 +
van Eys J, Flexner JM:  Transient spontaneous remission in a case of untreated congenital leukemia . Amer J Dis Child 118:507-514, 1969;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Wells HG:  Occurrence and significance of congenital malignant neoplasms . Arch Path 30:535-601, 1940;.
2 +
Bolande RP: Cellular Aspects of Developmental Pathology . Philadelphia, Lea & Febiger, 1967;.
3 +
Everson TC, Cole, WH: Spontaneous Regression of Cancer . Philadelphia, WB Saunders Co, 1966;.
4 +
Bolande RP, Brough AJ, Izant RJ, Jr:  Congenital mesoblastic nephroma of infancy . Pediatrics 40:272-278, 1967;.
5 +
Klapproth HJ:  Wilms' tumor: A report of 45 cases and an analysis of 1,351 cases reported in the world literature from 1940 to 1958 . J Urol 81:633-648, 1959;.
6 +
Favara BE, Johnson W, Ito J:  Renal tumors in the neonatal period . Cancer 22:845-855, 1968;.
7 +
Wigger HJ:  Fetal hamartoma of the kidney . Amer J Clin Path 51:323-337, 1969;.
8 +
Richmond H, Dougall AJ:  Neonatal renal tumors . J Pediat Surg 5:413-418, 1970;.
9 +
Bachmann KD, Kroll W:  Der Wilms-Tumor in Ersten Lebensjahr insbesondere über 62 Nephroblastome des Neugeborenen . Deutsch Med Wschr 94:2598-2601, 1969;.
10 +
Sutow WW, Gehan EA, Heyn RM, et al:  Comparison of survival curves, 1956 versus 1962, in children with Wilms' tumor and neuroblastoma: Report of the Subcommittee on Childhood and Solid Tumors . Pediatrics 45:800-811, 1970;.
11 +
Gross RE, Farber S, Martin LW:  Neuroblastoma sympatheticum: A study and report of 217 cases . Pediatrics 23:1179-1191, 1959;.
12 +
 Survey on neuroblastoma among the surgical fellows of the American Academy of Pediatrics. In conference on the biology of neuroblastoma . J Pediat Surg 3:191-193, 1968;.
13 +
Schneider KM, Becker JM, Krasna IH:  Neonatal neuroblastoma . Pediatrics 36:359-366, 1965;.
14 +
Bachmann KD, Kroll W:  Über das pranatal enstandene. Neuroblastoma sympathicum . Kinderheilk 103:61-72, 1962;.
15 +
Kissane JM, Ackerman LV:  Maturation of tumor of the sympathetic nervous system . J Fac Radiologists 7:109-114, 1955;.
16 +
Haber EL, Bennington JL:  Maturation of congenital extraadrenal neuroblastoma . Arch Path 16:121-125, 1962;.
17 +
Visfeldt J:  Transformation of sympathicoblastoma into ganglioneuroma . Acta Path Microbiol Scand 58:414-428, 1963;.
18 +
Goldman RL, Goldman AN, Winterling CC:  Maturation of tumors of the sympathetic nervous system . Cancer 18:1510-1516, 1965;.
19 +
Dyke PC, Mulkey DA:  Maturation of ganglioneuroblastoma to ganglioneuroma . Cancer 20:1343-1349, 1966;.
20 +
Wilkerson JA, van de Water JM, Goepfert H:  Role of embryonic induction in benign transformation of neuroblastomas . Cancer 20:1335-1342, 1967;.
21 +
Griffin ME, Bolande RP:  Familial neuroblastoma with regression and maturation to ganglioneurofibroma . Pediatrics 43:377-382, 1969;.
22 +
van Erp IFR:  Cutaneous metastases in neuroblastoma . Dermatologica 136:265-269, 1968;.
23 +
Aterman K:  Maturation of neuroblastoma to ganglioneuroma . Amer J Dis Child 120:217-222, 1970;.
24 +
Becker JM: Schneider KM, Krasna IH:  Neonatal neuroblastoma . Progr Clin Cancer 4:382-386, 1970;.
25 +
Coop CE:  Factors affecting survival in neuroblastoma. In conference on the biology of neuroblastoma . J Pediat Surg 3:113-114, 1968;.
26 +
Bolande RP, Towler WF:  A possible relationship of neuroblastoma to von Recklinghausen's disease . Cancer 26:162-175, 1970;.
27 +
Reilly D, Nesbit MD, Krivit W:  Cure of three patients who had skeletal metastases in disseminated neuroblastoma . Pediatrics 41:47-51, 1968;.
28 +
Beckwith JB, Perrin EV:  In situ neuroblastomas: A contribution to the natural history of neural crest tumors . Amer J Path 43:1089-1104, 1963;.
29 +
Guin GH, Gilbert EE, Jones B:  Incidental neuroblastoma in infants . Amer J Clin Path 51:126-135, 1969;.
30 +
Shanklin DR, Sotelo-Avila C:  In situ tumors in fetuses, newborn and young infants . Biol Neonat 14:286-316, 1969;.
31 +
Dillard BM, Mayer JH, McAlister WH, et al:  Sacrococcygeal teratoma in children . J Pediat Surg 5:53-59, 1970;.
32 +
Donnellan WA, Swenson O:  Benign and malignant sacrococcygeal teratomas . Surgery 64:834-846, 1968;.
33 +
van Eys J, Flexner JM:  Transient spontaneous remission in a case of untreated congenital leukemia . Amer J Dis Child 118:507-514, 1969;.

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