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The G Syndrome

James R. Little, MD; John M. Opitz, MD
Am J Dis Child. 1971;121(6):505-507. doi:10.1001/archpedi.1971.02100170087012.
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With respect to the communication by Coburn,1 the following data pertaining to the G syndrome may be of interest.

The G Family.—Patient 3 of our original paper2 (V-29, UWH No. 420651) is in good health; he is growing and maturing normally and he is an exceptionally intelligent boy (Figure). The stridorous nature of his respiration is unchanged; his hypospadias has been repaired and he is swallowing adequately. Recently the family moved and the new next-door neighbor turned out to be the widow of Mrs. G's uncle (III-1). From her it was learned that the mother (II-4) of the uncle and of Mrs. G's mother (III-5) had had a brother (II-2) with life-long stridorous respirations and a genital malformation—he was known in the family as "the hermaphrodite"; he may also have had a colostomy. He was married but childless. II-4, her brother II-6, and her son III-1 purportedly

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