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June 1971, Vol 121, No. 6 >
Article | June 1971

Rubella Immunization With HPV-77 DE5 Vaccine During Infancy FREE

Kenneth L. Herrmann, MD; Reuben D. Wende; John J. Witte, MD
[+] Author Affiliations

Received for publication March 19, 1971.

Reprint requests to Virology Section, Center for Disease Control, Atlanta 30333 (Dr. Herrmann).


Am J Dis Child. 1971;121(6):474-476. doi:10.1001/archpedi.1971.02100170056004.
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One hundred and thirty-seven infants, 6 to 12 months of age, were given live rubella vaccine to more clearly define the efficacy of rubella immunization under 1 year of age and to correlate passively acquired rubella antibody with response to rubella vaccine. By testing serial blood specimens taken from ten infants from birth to 6 months of age, we defined the half-life of rubella HI antibody as 30 days; our data supported the observation that rubella HI antibody is rarely detectable after 6 months of age. In this study population, no rubella HI antibody was detectable in any study participant at the time of vaccine inoculation. However, only 69% of the infants under 10 months of age seroconverted after rubella vaccine inoculation, whereas over 90% of those 10 months of age and older responded positively. No correlation between failure to seroconvert and levels of passively acquired rubella antibody at birth was found. Results of this study suggest that other age related factors are of major importance in influencing the immunologic response of the infant to live rubella vaccine.

REFERENCES

1 +
Parkman PD, Meyer HM Jr, Kirchstein RL, et al:  Attenuated rubella virus: I. Development and laboratory characterization . New Eng J Med 275:569-574, 1966;.
2 +
Meyer HM Jr, Parkman PD, Panos TC:  Attenuated rubella virus: II. Production of an experimental live-virus vaccine and clinical trial . New Eng J Med 275:575-580, 1966;.
3 +
Pavilanis V, Chagnon A, Davignon L, et al:  Vaccination of infants with HPV-77 vaccine . Amer J Dis Child 118:247-251, 1969;.
4 +
Halonen PE, Ryan JM, Stewart JA:  Rubella hemagglutinin prepared with alkaline extraction of virus grown in suspension culture of BHK-21 cells . Proc Soc Exp Biol Med 125:162-167, 1967;.
5 +
 Recommendations of the Public Health Service Advisory Committee on immunization practices for rubella virus vaccines . Morbidity Mortality Weekly Rep 19:338-339, 1970;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Parkman PD, Meyer HM Jr, Kirchstein RL, et al:  Attenuated rubella virus: I. Development and laboratory characterization . New Eng J Med 275:569-574, 1966;.
2 +
Meyer HM Jr, Parkman PD, Panos TC:  Attenuated rubella virus: II. Production of an experimental live-virus vaccine and clinical trial . New Eng J Med 275:575-580, 1966;.
3 +
Pavilanis V, Chagnon A, Davignon L, et al:  Vaccination of infants with HPV-77 vaccine . Amer J Dis Child 118:247-251, 1969;.
4 +
Halonen PE, Ryan JM, Stewart JA:  Rubella hemagglutinin prepared with alkaline extraction of virus grown in suspension culture of BHK-21 cells . Proc Soc Exp Biol Med 125:162-167, 1967;.
5 +
 Recommendations of the Public Health Service Advisory Committee on immunization practices for rubella virus vaccines . Morbidity Mortality Weekly Rep 19:338-339, 1970;.

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