To the Editor.—The association of familial neuroblastoma and trisomy 13, to our knowledge, has not been reported. For this reason such an unusual set of circumstances should be briefly noted.
A 2½-year-old white girl was admitted to the Boston Floating Hospital for Infants and Children with a three week history of pain in the lower extremities and low grade fever. A large abdominal mass extending to the iliac crest was palpated. Her bone marrow was almost completely replaced by tumor cells and she had an elevated level in the urine of vanillylmandelic acid (VMA). On laporatomy a large neuroblastoma of the left adrenal gland was found. The patient died after three months of treatment with various drugs, including cyclophosphamide, vincristine, and procarbazine hydrochloride (Natulan [Britain]; Matulane, comparable US product). One year after her death her mother delivered a female infant with multiple congenital anomalies. Approximately two to three months