A two-year-old Negro-South American girl presented with juvenile laryngeal papilloma which necessitated an emergency tracheostomy. During the next 1½ years of hospitalization, she required general anesthesia for surgical excision of recurrent growths on an average of once every 3.7 weeks. Inasmuch as the process continued unabated, autogenous vaccine prepared from her tumor was administered by 15 weekly injections. There was an apparent dramatic beneficial response with vocalization around the tracheostomy tube occurring for the first time within two months of the start of vaccine therapy. Tumor growth regressed completely, the tracheostomy tube was removed within six months of the utilization of vaccine treatment and the patient was discharged after two years of hospitalization.