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May 1971, Vol 121, No. 5 >
Article | May 1971

Familial Neuroblastoma FREE

Kwan-Yuen Wong, MB, BS; Irwin B. Hanenson, MD; Beatrice C. Lampkin, MD
[+] Author Affiliations

Received for publication Nov 2, 1970.

Reprint requests to Children's Hospital, Cincinnati 45229 (Dr. Wong).


Am J Dis Child. 1971;121(5):415-416. doi:10.1001/archpedi.1971.02100160085010.
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A diagnosis of neuroblastoma was made in two siblings, each at 5½ months of age. Both siblings are living and well, 2½ years and nine months, respectively, after surgery and x-ray therapy. The father had increased levels of 4-hydroxy-3-methoxymandelic acid (vanillylmandelic acid [VMA]) in his urine, but there was no clinical evidence of a neural tumor. The results of studies in this family suggest that neuroblastoma may be inherited in an autosomal dominant pattern after mutation of the genes governing the neural crest formation.

REFERENCES

1 +
Chatten J, Voorhess ML:  Familial neuroblastoma: Report of a kindred with multiple disorders, including neuroblastomas in four siblings . New Eng J Med 277:1230-1236, 1967;.
2 +
Miller RW, Fraumeni JF Jr, Hill JA:  Neuroblastoma: Epidemiologic approach to its origin . Amer J Dis Child 115:253-261, 1968;.
3 +
Wilfrido MS, Edmonson JH:  The developmental defects associated with neuroblastoma—etiologic implications . Cancer 22:234-238, 1968;.
4 +
Crowe FW, Schull WJ, Neel JV: A Clinical, Pathological and Genetic Study of Multiple Neurofibromatosis . Springfield, Ill, Charles C Thomas Publisher, 1956;, p 168.
5 +
Carman CT, Brasher RE:  Pheochromocytoma as an inherited abnormality . New Eng J Med 263:419-423, 1960;.
6 +
Potter EL, Parrish JM:  Neuroblastoma, ganglioneuroma and fibroneuroma in a stillborn fetus . Amer J Path 18:141-151, 1942;.
7 +
Chapman RC, Kempe VE, Taliaferro I:  Pheochromocytoma associated with multiple neurofibromatosis and intracranial hemangioma . Amer J Med 26:883-890, 1959;.
8 +
Knudson AG Jr, Amromin GD:  Neuroblastoma and ganglioneuroma in a child with multiple neurofibromatosis . Cancer 19:1032-1037, 1966;.
9 +
Bolande RB, Towler WF:  A possible relationship of neuroblastoma to von Recklinghausen's disease . Cancer 26:162-175, 1970;.
10 +
Zimmermann J:  Ganglioneuroblastome als erbliche Systemerkrankung des Sympathicus . Beitr Path Anat 111:355-372, 1951;.
11 +
Beckwith JB, Perrin EV:  In situ neuroblastomas: A contribution to the natural history of neural crest tumors . Amer J Path 43:1089-1104, 1963;.
12 +
Helson L, Blasco P, Murphy ML:  Familial neuroblastoma . Clin Res 17:614, 1969;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Chatten J, Voorhess ML:  Familial neuroblastoma: Report of a kindred with multiple disorders, including neuroblastomas in four siblings . New Eng J Med 277:1230-1236, 1967;.
2 +
Miller RW, Fraumeni JF Jr, Hill JA:  Neuroblastoma: Epidemiologic approach to its origin . Amer J Dis Child 115:253-261, 1968;.
3 +
Wilfrido MS, Edmonson JH:  The developmental defects associated with neuroblastoma—etiologic implications . Cancer 22:234-238, 1968;.
4 +
Crowe FW, Schull WJ, Neel JV: A Clinical, Pathological and Genetic Study of Multiple Neurofibromatosis . Springfield, Ill, Charles C Thomas Publisher, 1956;, p 168.
5 +
Carman CT, Brasher RE:  Pheochromocytoma as an inherited abnormality . New Eng J Med 263:419-423, 1960;.
6 +
Potter EL, Parrish JM:  Neuroblastoma, ganglioneuroma and fibroneuroma in a stillborn fetus . Amer J Path 18:141-151, 1942;.
7 +
Chapman RC, Kempe VE, Taliaferro I:  Pheochromocytoma associated with multiple neurofibromatosis and intracranial hemangioma . Amer J Med 26:883-890, 1959;.
8 +
Knudson AG Jr, Amromin GD:  Neuroblastoma and ganglioneuroma in a child with multiple neurofibromatosis . Cancer 19:1032-1037, 1966;.
9 +
Bolande RB, Towler WF:  A possible relationship of neuroblastoma to von Recklinghausen's disease . Cancer 26:162-175, 1970;.
10 +
Zimmermann J:  Ganglioneuroblastome als erbliche Systemerkrankung des Sympathicus . Beitr Path Anat 111:355-372, 1951;.
11 +
Beckwith JB, Perrin EV:  In situ neuroblastomas: A contribution to the natural history of neural crest tumors . Amer J Path 43:1089-1104, 1963;.
12 +
Helson L, Blasco P, Murphy ML:  Familial neuroblastoma . Clin Res 17:614, 1969;.

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