Kartagener's syndrome is manifest by the association of sinusitis, situs inversus, and bronchiectasis. We treated three children with Kartagener's syndrome, two of them sisters. Respiratory symptoms began in infancy in all three patients. In case 1, a normal bronchogram was seen at 6 years of age; a second bronchogram at 13 years was grossly abnormal. Two patients required lobectomy for areas that did not clear with medical management. Immunoglobulin deficiency was not present and salivary IgA levels were normal. Early vigorous medical management might prevent the occurrence of bronchiectasis in patients with situs inversus.