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Thiabendazole in Visceral Larva Migrans

Rhomes J.A. Aur, MD; Charles B. Pratt, MD; Warren W. Johnson, MD
Am J Dis Child. 1971;121(3):226-229. doi:10.1001/archpedi.1971.02100140092008.
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Thiabendazole, a broad spectrum anti-helminthic agent, was administered to three children with visceral larva migrans in a dosage of 20 to 50 mg/kg daily for seven to ten days. The children had presented with fever, weight loss, anemia, lymphoadenopathy, hepatosplenomegaly, perihilar infiltrates, leukocytosis, and eosinophilia. This course was repeated after a four-week interval. After thiabendazole therapy, they demonstrated rapid clinical and laboratory improvement, contrasting with the prolonged duration of disease when no therapy is given. There was no evidence of drug-associated toxicity.


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