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Article |

Impairment of Cold-Stimulated Lipolysis by Acute Hypoxia

David Baum, MD; Courtney L. Anthony Jr., MD; Carol Stowers
Am J Dis Child. 1971;121(2):115-119. doi:10.1001/archpedi.1971.02100130069007.
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Cold stress led to elevated plasma glycerol and free fatty acid (FFA) levels in 12 airventilated puppies. In contrast to persisting high plasma glycerol and FFA levels in the control group, marked falls of these plasma constituents occurred in six animals made hypoxic. Returning the hypoxic puppies to air breathing resulted in partial recovery of prehypoxic elevations of plasma glycerol and FFA. These observations in puppies indicate that lipolysis stimulated by cold stress was inhibited by hypoxia. Since FFA is a major fuel for heat production, reduced lipolysis at low oxygen tensions may contribute to impaired thermogenesis in young hypoxic mammals.


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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