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Teratology of the Central Nervous System: Induced and Spontaneous Malformations of Laboratory, Agricultural, and Domestic Mammals

SIDNEY Q. COHLAN, MD
Am J Dis Child. 1970;120(1):91-92. doi:10.1001/archpedi.1970.02100060125034.
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ABSTRACT

The science of experimental mammalian teratology had its beginning 40 years ago and was catapulted into clinical and experimental prominence nine years ago by the Thalidomide catastrophy.

This is the first major text to provide a comprehensive view of the significant observations that have been made in studying the effects of radiation, drugs, chemicals, physical agents, and infection on the fetal development of the laboratory mammal.

Since the embryopathy produced by most of the known teratogens usually includes central nervous system defects, the author's restriction to central nervous malformations sacrifices little of the accumulated experimental teratologic experience.

The book is divided into two parts. In the first part, the author has remarkably managed to record in a concise, clear, easy-to-read style, most of the important observations made since the 1930s by a host of investigators using varied teratologic agents and procedures in a variety of laboratory animals. The second section

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