0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Wegener's Granulomatosis in a Child:  Observations on Pathogenesis and Treatment

Stacy A. Roback, MD; Roger C. Herdman, MD; John Hoyer, MD; Robert A. Good, MD, PhD
Am J Dis Child. 1969;118(4):608-614. doi:10.1001/archpedi.1969.02100040610014.
Text Size: A A A
Published online

WEGENER'S granulomatosis, a rare disease in adults, is particularly infrequent in children. Only three instances of this disorder in individuals less than 15 years of age have been reported.1-3 This communication concerns studies of a boy whose first symptoms of Wegener's granulomatosis occurred at 14 years of age. New observations relative to the pathogenesis and therapy of this disease are described.

Report of a Case  A 16-year-old white boy had the first of many episodes of spontaneous epistaxis at age 14. On several occasions, bleeding was severe enough to require hospitalization, yet at these times no abnormality of coagulation could be demonstrated. At 14½ years of age he developed nasal stuffiness, intermittent low-grade fever, lethargy, and anorexia. At this time, the histological condition of a nasal biopsy was interpreted as nonspecific granulation with minimal granuloma formation (Fig 1). Skin tests for mycobacteria were negative, and over a period

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();