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September 1969, Vol 118, No. 3 >
Article | September 1969

Congenital Cytomegalovirus Infection Associated With Multicystic Kidney FREE

Stanley A. Plotkin, MD; Patrick S. Pasquariello, MD
[+] Author Affiliations

Received for publication Feb 17, 1969.

Reprint requests to Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia 19104 (Dr. Plotkin).


Am J Dis Child. 1969;118(3):515-517. doi:10.1001/archpedi.1969.02100040517018.
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THE SPECTRUM of disease caused by congenital cytomegalovirus infection is gradually being expanded beyond the classic combination of hepatosplenomegaly, thrombocytopenia, and microcephaly.1 Milder forms of congenital infection have been described,2-4 and it is possible that some infants born infected will be totally asymptomatic. Recent surveys indicate that 1% to 2% of ostensibly normal infants carry cytomegalovirus at birth.5 Since follow-up studies of these infected but asymptomatic infants have not yet been reported, the pathogenicity of the virus in these cases is uncertain.

The case report that follows concerns a newborn infant with undoubted cytomegalovirus infection, who also had a cystic horseshoe kidney. Speculation concerning the relationship of the two findings is presented.

Report of a Case  The patient is a male first-born child. No unusual incidents or minor illnesses occurred during the pregnancy of his mother who was 32 years of age. Labor and delivery were normal.

REFERENCES

1 +
Weller, T.H., and Hanshaw, J.B.:  Virologic and Clinical Observation on Cytomegalic Inclusion Disease , New Eng J Med 266:1233-1244 ( (June 14) ) 1962;.
2 +
Emanuel, I., and Kenny, G.E.:  Cytomegalic Inclusion Disease of Infancy , Pediatrics 38:957-965 ( (Dec) ) 1966;.
3 +
Benyesh-Melnick, M.; Rosenberg, H.S.; and Watson, B.:  Viruses in Cell Cultures of Kidneys of Children With Congenital Heart Malformations and Other Diseases , Proc Soc Exp Biol Med 117:452-459 ( (Nov) ) 1964;.
4 +
Hanshaw, J.B.:  Congenital and Acquired Cytomegalovirus Infection , Pediat Clin N Amer 13:279-293 ( (March) ) 1966;.
5 +
Hanshaw, J.B.; Steinfeld, H.J.; and White, C.J.:  Fluorescent-Antibody Test for Cytomegalovirus Macroglobulin , abstracted, New Eng J Med 279:566-570 ( (Sept 12) ) 1968;.
6 +
Stern, H., and Tucker, S.M.:  Cytomegalovirus Infection in the Newborn and in Early Childhood , Lancet 2:1268-1271 ( (Dec 18) ) 1965;.
7 +
Lang, D.J.:  The Association of Indirect Inguinal Hernia With Congenital Cytomegalic Inclusion Disease , Pediatrics 38:913-916 ( (Nov) ) 1966;.
8 +
Bradford, W.D., et al:  Cystic Disease of Liver and Kidney With Portal Hypertension: A Cause of Sudden Unexpected Hematemesis , Clin Pediat 7:299-306 ( (March) ) 1968;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Weller, T.H., and Hanshaw, J.B.:  Virologic and Clinical Observation on Cytomegalic Inclusion Disease , New Eng J Med 266:1233-1244 ( (June 14) ) 1962;.
2 +
Emanuel, I., and Kenny, G.E.:  Cytomegalic Inclusion Disease of Infancy , Pediatrics 38:957-965 ( (Dec) ) 1966;.
3 +
Benyesh-Melnick, M.; Rosenberg, H.S.; and Watson, B.:  Viruses in Cell Cultures of Kidneys of Children With Congenital Heart Malformations and Other Diseases , Proc Soc Exp Biol Med 117:452-459 ( (Nov) ) 1964;.
4 +
Hanshaw, J.B.:  Congenital and Acquired Cytomegalovirus Infection , Pediat Clin N Amer 13:279-293 ( (March) ) 1966;.
5 +
Hanshaw, J.B.; Steinfeld, H.J.; and White, C.J.:  Fluorescent-Antibody Test for Cytomegalovirus Macroglobulin , abstracted, New Eng J Med 279:566-570 ( (Sept 12) ) 1968;.
6 +
Stern, H., and Tucker, S.M.:  Cytomegalovirus Infection in the Newborn and in Early Childhood , Lancet 2:1268-1271 ( (Dec 18) ) 1965;.
7 +
Lang, D.J.:  The Association of Indirect Inguinal Hernia With Congenital Cytomegalic Inclusion Disease , Pediatrics 38:913-916 ( (Nov) ) 1966;.
8 +
Bradford, W.D., et al:  Cystic Disease of Liver and Kidney With Portal Hypertension: A Cause of Sudden Unexpected Hematemesis , Clin Pediat 7:299-306 ( (March) ) 1968;.

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