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August 1969, Vol 118, No. 2 >
Article | August 1969

Attenuated Rubella Virus Vaccines in Children With Tuberculosis:  Clinical Trials FREE

André Boué, MD; Josette Celers, MD
[+] Author Affiliations

Received for publication March 4, 1969.

Read before the International Conference of Rubella Immunization, Bethesda, Md, Feb 19, 1969.

Reprint requests to Laboratory of S.E.S.E.P., Château de Longchamp, Paris 16 (Dr. Boué).


Am J Dis Child. 1969;118(2):258-260. doi:10.1001/archpedi.1969.02100040260019.
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IN ORDER TO demonstrate the lack of communicability of attenuated rubella virus strains, clinical trials have been performed in institutions housing closed populations of children. We report here the results of clinical trials of live rubella virus vaccines undertaken in an institution for young children with pulmonary tuberculosis. This institution was selected for study because the conditions of isolation and of medical surveillance were very good.

Materials and Methods  Vaccines.—Two attenuated rubella virus vaccines were used: (1) HPV-77 vaccine prepared in green monkey kidney tissue cultures, and (2) RA 27/3 vaccine prepared in WI 38 human diploid cell lines. Each vaccinated child received 0.5 ml subcutaneously.Study Population and Experimental Design.—This study was done in the isolation unit of the "Centre de Protection Infantile" of Bullion, an institution for treatment of children less than 5 years of age with pulmonary tuberculosis. This institution is located in the

REFERENCES

1 +
Boué, A., and Deshayes, E.:  Technique indirecte de seroneutralisation du virus de la rubéole sur les cellules diploides humaines , Path Biol 15:324-328 ( (March) ) 1967;.
2 +
Stewart, G.L., et al:  Rubella Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March 9) ) 1967;.
3 +
Boué, A.; Nicolas, A.; and Lang, R.:  La réaction d'inhibition de L'hémagglutination pour la serologie de la rubéole , Ann Inst Pasteur 114: 317-330 ( (March) ) 1968;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Boué, A., and Deshayes, E.:  Technique indirecte de seroneutralisation du virus de la rubéole sur les cellules diploides humaines , Path Biol 15:324-328 ( (March) ) 1967;.
2 +
Stewart, G.L., et al:  Rubella Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March 9) ) 1967;.
3 +
Boué, A.; Nicolas, A.; and Lang, R.:  La réaction d'inhibition de L'hémagglutination pour la serologie de la rubéole , Ann Inst Pasteur 114: 317-330 ( (March) ) 1968;.

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