August 1969, Vol 118, No. 2 >

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Article | August 1969

Immunization With Live Attenuated Rubella Virus Vaccine (HPV-77): Clinical and Serological Results in Children and Adolescents in Israel

Natan Goldblum, PhD; Tiberio A. Swartz, MD; Wanda Klingberg, PhD; Robert A. Goldwasser, PhD; Marcus A. Klingberg, MD

Am J Dis Child. 1969;118(2):190-196. doi:10.1001/archpedi.1969.02100040192006.

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THE experience with live attenuated rubella virus vaccines which has accumulated in the last few years shows a clear need for a rubella vaccine that is not only safe and effective, but also has few or no side affects when recommended as a routine procedure. Age seems to affect the intensity of the clinical response to vaccine administration, and, since joint manifestations have been reported in adult women immunized with rubella vaccine,^1-3 it was considered desirable to study the age effect further by investigating the clinical and serological reactions in a broad age spectrum of susceptible women.

For this purpose a field trial was initiated in Israel during the autumn and winter months of 1968 and 1969 which included a representative number of female subjects of various ages. The preliminary observations of the trial are presented in this report.

Materials and Methods Study Group.—This group included 239 girls,

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Goldblum N, Swartz TA, Klingberg W, Goldwasser RA, Klingberg MA. Immunization With Live Attenuated Rubella Virus Vaccine (HPV-77): Clinical and Serological Results in Children and Adolescents in Israel. Am J Dis Child. 1969;118(2):190-196. doi:10.1001/archpedi.1969.02100040192006.

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Immunization With Live Attenuated Rubella Virus Vaccine (HPV-77): Clinical and Serological Results in Children and Adolescents in Israel

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