We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Corticosteroid Treatment in Bronchiolitis A Controlled, Collaborative Study in 297 Infants and Children

John A. Leer Jr., MD, MSc (P); John L. Green, MD; Ernest M. Heimlich, MD; John S. Hyde, MD; Hugh L. Moffet, MD; Gordon A. Young, MD; Bruce A. Barron, PhD
Am J Dis Child. 1969;117(5):495-503. doi:10.1001/archpedi.1969.02100030497001.
Text Size: A A A
Published online


A DOUBLE-BLIND study on the effect of betamethasone sodium phosphate in the treatment of 297 infants and children with acute bronchiolitis was conducted at five hospitals from December 1963 to June 1965. For this study, the investigators designed a common protocol and standard case report forms for use at the five collaborating centers. The information obtained permitted an evaluation of the effects of the corticosteroid in bronchiolitis and provided further insight into the natural history of the disease. The study was not designed to explore the causes of bronchiolitis or the effect of supportive treatment.

In recent years, corticosteroids have been used in the treatment of bronchiolitis on the hypothesis that their anti-inflammatory action would reduce bronchiolar inflammation and swelling. These drugs have been regarded as ineffective by some investigators and lifesaving by others. In 1964, Sussman et al1 reported no change in the clinical course of 49 bronchiolitic


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.