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Diabetes Mellitus:  Incidence in Families of Children With Nephrotic Syndrome

James C. M. Chan, MD; Edmund C. Burke, MD; Gunnar B. Stickler, MD
Am J Dis Child. 1969;117(4):442-444. doi:10.1001/archpedi.1969.02100030444010.
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THE PURPOSE of this study was to determine whether or not there is an increased incidence of diabetes mellitus in the families of children with nephrotic syndrome. Such a relationship has been alluded to by Dr. J. D. Crawford, Harvard Medical School, at a case presentation on Sept 20, 1965 while visiting our institution, but so far no data have been published. Furthermore, a possible association was suggested by the observation of two patients in whom nephrotic syndrome occurred early in the course of diabetes mellitus but without the histologic lesions of Kimmelstiel-Wilson nephropathy.

Materials and Methods  Patients.—One hundred twenty-five children with nephrotic syndrome seen at the Mayo Clinic in the years 1953 through 1962 were used as the study probands. The mean age of these children was 5 years at the time of their initial visit. All of them were of Caucasian extraction except one Chinese boy.For

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