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February 1969, Vol 117, No. 2 >
Article | February 1969

Diabetes Insipidus Complicating Acute Lymphocytic Leukemia

Ira J. Malter, MD; Samuel Gross, MD; Thomas M. Teree, MD
Am J Dis Child. 1969;117(2):228-230. doi:10.1001/archpedi.1969.02100030230020.
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DIABETES insipidus complicating acute leukemia has been reported but rarely. In a comprehensive review Rosensweig and Kendall1 found 12 such cases, only one of which was in a child. The patient was recorded to have had acute granulocytic leukemia.2 Of the remaining 11 adult patients, only one had acute lymphocytic leukemia.3 This report presents the first well-documented case of diabetes insipidus complicating acute lymphocytic leukemia in a child.

Report of a Case  A 10-year-old Negro girl with acute lymphocytic leukemia was admitted to the Children's Clinical Research Center of University Hospitals of Cleveland in August 1967 following one month of polyuria and polydipsia.She had first presented ten months earlier with fever, dyspnea, and chest pain at which time a left pleural effusion was noted radiographically. Thoracentesis followed by biopsy and examination of scalene and anterior mediastinal lymph nodes established a diagnosis of lymphocytic lymphoma. Other abnormal

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