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Cancer Deaths in the Newborn FREE

Joseph F. Fraumeni, MD; Robert W. Miller, MD
[+] Author Affiliations

Received for publication Aug 16, 1968.

Reprint requests to 410 Wiscon Bldg, National Institutes of Health, 9000 Rockville Pike, Bethesda, Md 20014 (Dr. Fraumeni).


Am J Dis Child. 1969;117(2):186-189. doi:10.1001/archpedi.1969.02100030188011.
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WELLS,1 in his classical review of 250 malignant neoplasms present at birth, expressed the belief that the induction of congenital neoplasia "must differ in some fundamental way from the ordinary sorts of cancer, which require so long a period for development, and this difference may throw some light on the mystery of malignancy." Reported here is a further exploration into the origins of congenital neoplasia through a study of the US national mortality from cancer within the first 28 days of life over a five-year interval.

Methods  The National Vital Statistics Division, United States Public Health Service, provided us with 21,929 copies of death certificates (international list numbers 140-205) for all children under 15 years of age who died of cancer in the United States during the five-year period, 1960 to 1964. Excluded from analysis were 270 children, including five neonates, who died with malignant histiocytosis. Of the remaining

REFERENCES

Wells, H.G.:  Occurrence and Significance of Congenital Malignant Neoplasms , Arch Path 30: 535-601 ( (Aug) ) 1940;.
Heasman, M.A., and Lipworth, L.: Accuracy of Certification of Cause of Death (Studies on Medical and Population Subjects No. 20) , London: Her Majesty's Stationery Office, 1966;.
Alderson, M.R., and Meade, T.W.:  Accuracy of Diagnosis on Death Certificates Compared With That in Hospital Records , Brit J Prev Soc Med 21: 22-29 ( (Jan) ) 1967;.
Ederer, F.; Myers, M.H.; and Mantel, N.:  A Statistical Problem in Space and Time: Do Leukemia Cases Come in Clusters? Biometrics 20: 626-638 ( (Sept) ) 1964;.
Miller, R.W.:  Down's Syndrome (Mongolism), Other Congenital Malformations and Cancers Among the Sibs of Leukemic Children , New Eng J Med 268:393-401 ( (Feb 21) ) 1963;.
Schneider, K.M.; Becker, J.M.; and Krasna, I.H.:  Neonatal Neuroblastoma , Pediatrics 36:359-366 ( (Sept) ) 1965;.
Pierce, M.I.:  Leukemia in the Newborn Infant , J Pediat 54:691-706 ( (May) ) 1959;.
Ederer, F.; Miller, R.W.; and Scotto, J.:  US Childhood Cancer Mortality Patterns, 1950-1959: Etiologic Implications , JAMA 192:593-596 ( (May 17) ) 1965;.
Fraumeni, J.F., Jr., and Wagoner, J.K.:  Changing Sex Differentials in Leukemia , Public Health Rep 79:1093-1100 ( (Dec) ) 1964;.
Campbell, W.A.B.; MacAfee, A.L.; and Wade, W.G.:  Familial Neonatal Leukaemia , Arch Dis Child 37:93-98 ( (Feb) ) 1962;.
Bouton, M.J., et al:  Congenital Leukaemia With Parental Consanguinity: Case Report With Chromosome Studies , Brit Med J 2:866-869 ( (Sept 30) ) 1961;.
Bartlett, R.C.; Otis, R.D.; and Laakso, A.O.:  Multiple Congenital Neoplasms of Soft Tissues: Report of 4 Cases in 1 Family , Cancer 14:913-920 ( (Sept) -Oct) 1961;.
Miller, R.W.:  Relation Between Cancer and Congenital Defects in Man , New Eng J Med 275: 87-93 ( (July 14) ) 1966;.
Lashof, J.C., and Stewart, A.:  Oxford Survey of Childhood Cancers; Progress Report III: Leukaemia and Down's Syndrome , Monthly Bull Minist Health 24:136-143 ( (June) ) 1965;.
Ross, J.D.; Moloney, W.C.; and Desforges, J.F.:  Ineffective Regulation of Granulopoiesis Masquerading as Congenital Leukemia in a Mongoloid Child , J Pediat 63:1-10 ( (July) ) 1963;.
Carr, D.H.:  Chromosome Anomalies as a Cause of Spontaneous Abortion , Amer J Obstet Gynec 97:283-293 ( (Feb) ) 1967;.
Bernhard, W.G.; Gore, I.; and Kilby, R.A.:  Congenital Leukemia , Blood 6:990-1001 ( (Nov) ) 1951;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Wells, H.G.:  Occurrence and Significance of Congenital Malignant Neoplasms , Arch Path 30: 535-601 ( (Aug) ) 1940;.
Heasman, M.A., and Lipworth, L.: Accuracy of Certification of Cause of Death (Studies on Medical and Population Subjects No. 20) , London: Her Majesty's Stationery Office, 1966;.
Alderson, M.R., and Meade, T.W.:  Accuracy of Diagnosis on Death Certificates Compared With That in Hospital Records , Brit J Prev Soc Med 21: 22-29 ( (Jan) ) 1967;.
Ederer, F.; Myers, M.H.; and Mantel, N.:  A Statistical Problem in Space and Time: Do Leukemia Cases Come in Clusters? Biometrics 20: 626-638 ( (Sept) ) 1964;.
Miller, R.W.:  Down's Syndrome (Mongolism), Other Congenital Malformations and Cancers Among the Sibs of Leukemic Children , New Eng J Med 268:393-401 ( (Feb 21) ) 1963;.
Schneider, K.M.; Becker, J.M.; and Krasna, I.H.:  Neonatal Neuroblastoma , Pediatrics 36:359-366 ( (Sept) ) 1965;.
Pierce, M.I.:  Leukemia in the Newborn Infant , J Pediat 54:691-706 ( (May) ) 1959;.
Ederer, F.; Miller, R.W.; and Scotto, J.:  US Childhood Cancer Mortality Patterns, 1950-1959: Etiologic Implications , JAMA 192:593-596 ( (May 17) ) 1965;.
Fraumeni, J.F., Jr., and Wagoner, J.K.:  Changing Sex Differentials in Leukemia , Public Health Rep 79:1093-1100 ( (Dec) ) 1964;.
Campbell, W.A.B.; MacAfee, A.L.; and Wade, W.G.:  Familial Neonatal Leukaemia , Arch Dis Child 37:93-98 ( (Feb) ) 1962;.
Bouton, M.J., et al:  Congenital Leukaemia With Parental Consanguinity: Case Report With Chromosome Studies , Brit Med J 2:866-869 ( (Sept 30) ) 1961;.
Bartlett, R.C.; Otis, R.D.; and Laakso, A.O.:  Multiple Congenital Neoplasms of Soft Tissues: Report of 4 Cases in 1 Family , Cancer 14:913-920 ( (Sept) -Oct) 1961;.
Miller, R.W.:  Relation Between Cancer and Congenital Defects in Man , New Eng J Med 275: 87-93 ( (July 14) ) 1966;.
Lashof, J.C., and Stewart, A.:  Oxford Survey of Childhood Cancers; Progress Report III: Leukaemia and Down's Syndrome , Monthly Bull Minist Health 24:136-143 ( (June) ) 1965;.
Ross, J.D.; Moloney, W.C.; and Desforges, J.F.:  Ineffective Regulation of Granulopoiesis Masquerading as Congenital Leukemia in a Mongoloid Child , J Pediat 63:1-10 ( (July) ) 1963;.
Carr, D.H.:  Chromosome Anomalies as a Cause of Spontaneous Abortion , Amer J Obstet Gynec 97:283-293 ( (Feb) ) 1967;.
Bernhard, W.G.; Gore, I.; and Kilby, R.A.:  Congenital Leukemia , Blood 6:990-1001 ( (Nov) ) 1951;.

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