January 1969, Vol 117, No. 1 >

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Article | January 1969

Results of Mass Screening for Hyperaminoacidemias in the Newborn Infant

carol Clow; Charles R. Scriver, MD; Eluned Davies, AIST

Am J Dis Child. 1969;117(1):48-53. doi:10.1001/archpedi.1969.02100030050005.

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OPPORTUNITIES to survey the newborn human infant for the occurrence of a wide variety of aminoacidopathies and to determine "normal" variation in plasma amino acid composition at this age have been rather limited. Most mass screening programs have focused on a single amino acid. The adaptation of simple modified partition chromatographic techniques^1,2 to the analysis of amino acids in whole blood or plasma provided the opportunity to perform mass screening for many aminoacidopathies and to evaluate the worth of this endeavor. It was a subject of great interest to Dr. Efron,³ and one which she pioneered with Dr. MacCready and other colleagues until she could work no longer.

In this communication we report on a survey of 36,172 infants, in whom a measured volume of plasma was examined by partition chromatography. Our report follows that completed by Dr. Levy⁴ after Dr. Efron died, in which her survey

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Clow c, Scriver CR, Davies E. Results of Mass Screening for Hyperaminoacidemias in the Newborn Infant. Am J Dis Child. 1969;117(1):48-53. doi:10.1001/archpedi.1969.02100030050005.

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