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Blood and Urine Amino Acid Aberrations:  Physiologic and Pathological Changes in Patients Without Inborn Errors of Amino Acid Metabolism

Ralph D. Feigin, MD
Am J Dis Child. 1969;117(1):24-47. doi:10.1001/archpedi.1969.02100030026004.
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NORMAL values for plasma and urinary amino acids have been presented in a number of studies.1-7 The range of reported values is great and varies from one study to another. Despite these differences, the definition of normal values has permitted the recognition in man of many inborn errors of amino acid metabolism. These primary aminoacidurias have been the subject of two recent reviews.8,9 During the past several decades, blood and urine amino acid changes have also been defined in a large number of disorders characterized by secondary aminoaciduria and in a variety of physiologic states. The concept of normality in terms of a static blood amino acid concentration has also been challenged. This article classifies and reviews those physiologic and pathologic amino acid changes described in man which are not the result of a known inborn error of amino acid metabolism. Specific emphasis is placed upon the possibility


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